| Objective:Abnormal serum lipid levels and the occurrence of tumors are common among older adults.In recent years,domestic and overseas research has shown that in addition to being a high risk factor for atherosclerotic cardiovascular disease(ASCVD),dyslipidemia can also lead to an increased risk of cancer.The purpose of this study was to investigate the association between gynecologic tumors and serum lipid levels in older female patients.Methods:We retrospectively reviewed the data of hospitalized older female patients obtained from the geratology and gynecology ward at the first affiliated hospital of Dalian medical university between January 2014 and December 2016.All patients were over 60 years old and clinical data included age,diagnosis,and hospitalized serum lipid test results.All diagnoses were confirmed by surgical pathology results.Selected cases of criteria filtered by inclusion and exclusion were divided into the following three groups:the elderly gynecologic benign tumor group,consisting of cases of cervical intraepithelial neoplasia(CIN),uterine myoma,adenomyosis,endometriosis,ovarian cyst,ovarian mature teratoma,ovarian theca cell tumor,ovarian serous cystadenoma and ovarian mucinous cystadenoma;elderly gynecologic malignant tumor group,consisting of cases of cervical cancer,endometrial cancer,ovarian granulosa cell tumor,ovarian serous cystadenocarcinoma and ovarian mucinous cystadenocarcinoma;and healthy older female group.In this retrospective clinical study,data was collected from each group for lipid levels,and serum lipid inspection projects including total cholesterol(TG),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),and lipoprotein(a)[Lp(a)].The measurement data were represented as X ± S,and they were obtained through normality and F testing.To conform to the normal distribution and homogeneity of variance data through variance analysis and multiple comparison(Tukey test),the data did not accord with the normal distribution data obtained from nonparametric tests.Correlation between variables was obtained using logistics regression analysis.P<0.05 was statistically significant.Results:The three groups,namely the older gynecologic benign tumor group(n = 130),older gynecologic malignant tumor group(n = 159),and older healthy female group(n =141)had mean ages of 65.32 ± 4.77,66.40 ± 6.36,and 65.65±5.86 years,respectively.There were no significant between-groups differences in their age(P = 0.252).The serum TC,TG,LDL-C,HDL-C and Lp(a)levels differed significantly among the three groups(P<0.0001),whereas the differences in HDL-C and Lp(a)levels were nonsignificant(P=0.104 and 0.880,respectively).The TC,LDL-C and TG levels of the benign tumor group and malignant tumor group were significantly differences with those of the healthy group(both P<0.0001),but the differences between the benign tumor and malignant tumor groups were nonsignificant for TC(P = 0.927),TG(P = 0.985)and LDL-C(P =0.954)levels.In the elderly gynecologic benign and malignant tumor groups,the relative risk was 38.865 and 15.48 for TC(both P<0.0001),0.128 and 0.321 for HDL-C(P =0.055 and 0.202),1.088 and 1.056 for LDL-C(P = 0.022 and 0.001),5.856 and 3.5975 for TG(P = 0.0001 and 0.001),and 0.998 and 0.999 for Lp(a)(P = 0.199 and 0.324),respectively.Conclusion:Serum TC,TG,and LDL-C levels in older patients with benign and malignant gynecological tumors differed from those of elderly healthy women,but there was no association between HDL-C and Lp(a)levels.Furthermore,were no marked differences in serum lipid levels between benign and malignant gynecological tumors.Serum TC,TG,and LDL-C levels are risk factors for elderly benign and malignant gynecologic tumors. |
