| Objective and Significance:To explore the significance and value of Aidi injection in the treatment of malignant tumors by clinical observation of the curative effect of Aidi injection combined with chemotherapy or radiotherapy and chemotherapy for gynecological malignant tumors(cervical cancer,endometrial cancer,ovarian cancer,fallopian tube cancer)after operation,and to provide a reference basis for further clinical promotion.Methods:100 patients with gynecological malignant tumors(including cervical cancer,endometrial cancer,ovarian cancer and fallopian tube cancer)were randomly divided into treatment group and control group,50 cases in each group.The control group was treated with TP or TC regimen.Cervical cancer and endometrial cancer were treated with concurrent radiotherapy.The treatment group was treated With 100 ml Aidi injection(0.9%normal saline with 500 ml)intravenously on the basis of the control group.Before and after treatment,the levels of CA125,TCM clinical symptom score,toxicity and side effects of radiotherapy and chemotherapy,KPS physical strength score,body weight and quality of life were observed and evaluated.Result:(1)As for the level of CA125,the level of tumor markers in the two groups was lower than before,and the decrease in the treatment group was more obvious than that in the control group,the difference was statistically significant.(2)In terms of clinical symptoms of TCM,there was no statistical difference in scores and total scores of clinical symptoms of TCM between the two groups before treatment.After treatment,the remission rate of symptoms of lower abdominal pain,fatigue and abnormal vaginal discharge in the treatment group was significantly better than that in the control group,and the difference was statistically significant;there was no statistical difference between the two groups in the remission rate of clinical symptoms of lower abdominal distention,mass and vaginal bleeding;the total integral value:the improvement rate of the treatment group(74.00%)was significantly higher than that of the control group(48.00%),with statistical significance.(3)In the side effects of radiotherapy and chemotherapy,the incidence of bone marrow hematopoietic suppression,gastrointestinal reaction and peripheral neurotoxicity in the treatment group was significantly lower than that in the control group,with statistical significance.There was no significant difference in hair loss,allergy and cardiotoxicity between the two groups.(4)Quality of life was assessed by Karnofsky KPS score,body weight and the European Organization for Reasearch and Treatment of Cancer Quality of Life Questionnare-Core 30(EORTC QLQ-C30)score:1.KPS physical strength score:there was no significant difference between the two groups before treatment.After treatment,the stability rate of KPS physical strength score change in treatment group(86.00%)was higher than that in control group(74.00%),The difference was statistically significant.2.Weight:Before treatment,there was no significant difference in body weight between the two groups.After treatment,the stable rate of weight change in the treatment group(62.00%)was significantly higher than that in the control group(44.00%),and the difference was statistically significant.3.In the aspect of quality of life(EORTC QLQ-C30),the score includes seven dimensions:body,role,emotion,cognition,social function,and the correlation between physical symptoms and health economy.Before treatment,there was no statistical difference in the baseline scores of seven dimensions between the two groups.After treatment,the two groups were compared in five dimensions:body,role,emotion,social function and physical symptoms.After treatment,the scores of the degree of treatment were significantly improved,with statistical differences.There was no significant difference between the two groups in the dimensions of cognitive function and health-economic correlation after treatment.Compared with the two groups after treatment,the scores of the treatment group in three dimensions of physical,emotional function and physical symptoms were significantly improved compared with those of the control group.There was statistical significance in the four dimensions of role,cognition,social function and health and economic correlation.There was no statistical difference in the scores between the two groups after treatment.Conclusion:Aidi injection can reduce the level of CA125,alleviate the clinical symptoms of patients with gynecological malignant tumors,alleviate the side effects of radiotherapy and chemotherapy,improve the quality of life of patients,and play a role in reducing toxicity and increasing efficiency. |
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