| Purpose:We conducted this analysis to investigate the effects and possible mechanisms of early intervention of Xuezhikang capsules on cognitive function,and the most suitable traditional Chinese medicine preparation to improve the cognitive functionin in elderly hypertensive patients.The objective was to provide a basis for preventing the high risk population of early cognitive impairment from developing vascular dementia.Methods:A total of 66 outpatients and inpatients admitted to Jiangsu Province Hospital were enrolled in the study.Among these,only 1 patients was excluded due to missing data,leaving 65 cases aging more than 60 years old with hypertension for the analysis.Finally,patients were divided into control group of 11 cases,Xuezhikang group of 29 cases,Statin group of 25 cases.The control group was given conventional treatment;Patients in Xuezhikang group were given conventional treatment plus Xuezhikang capsules 0.6g,2 times/day,morning and evening after taking;While Statin group was given conventional treatment plus statins lipid-lowering drugs,taked on an empty stomach in the morning,1 time/day;The time of treatment in all cases was three months.All subjects were followed up for three months and before treatment.For each patient,a routine initial clinical assessment including detailed clinical history,MMSE,MoCA,ADL and some inflammatory factors(IL-6,IL-8)were measured and evaluated.The total score and the subprojects of integral of MMSE,MoCA and ADL scales,and the changes on inflammatory factors(IL-6,IL-8)were calculated for each subject before and after the treatment,and used to assess risk within this study population.Results:(1)The total scores of MMSE and MoCA scales showed:There was no statistical difference among the three groups before receiving the treatment,the total scores of MMSE and MoCA scales had an increasing tendency in the three groups after treatment,and the total score of Xuezhikang group was the most obvious,but the differences among the three groups were not statistically significant(P>0.05).Intra-group comparison,the three groups had a higher trend of the total scores after treatment,but the differences were not statistically significant compared with that of before therapy(P>0.05).(2)MMSE scale subprojects suggested:Comparison among groups,the differences of MMSE scales subprojects were not statistically significant among the three groups before treatment.After treatment,Xuezhikang group and Statin group had an increasing tendency in the memory,while Xuezhikang group and control group had an increasing tendency in the language ability,but the differences were not statistically significant(P>0.05).Intra-group comparison,after treatment,Xuezhikang group of memory and language ability scores had an increasing tendency,but there was no significant change in the other subprojects,but the differences were not statistically significant(P>0.05).The scores of memory had an increasing tendency in Statin group,but there was no significant change in the other subprojects after treatment,but the differences were not statistically significant compared with that of before therapy(P>0.05).Control group of the language ability scores had an increasing tendency,but there was no significant change in the other subprojects after treatment,the differences were not statistically significant compared with that of before therapy(P>0.05).(3)MoCA scale subprojects suggested:Comparison among groups,there was a statistical difference in attention between Statin group and control group(P=0.045<0.05),while the differences among the rest subprojects in three groups were not obvious.After treatment,the language ability scores of Xuezhikang group and Statin group had an increasing tendency,the visuospatial/executive function scores of Statin group and control group had an increasing tendency,but the differences were not statistically significant(P>0.05).The attention scores of the three groups had a downward tendency,and the decline was the narrowest in Xuezhikang group,but the difference was not statistically significant(P>0.05).Intra-group comparison,after treatment,the score of the language ability in Xuezhikang group was significantly improved,the difference was statistically significant compared with that of before therapy(P=0.046<0.05),and memory scores had an increasing tendency,but there was no significant change in the other subprojects,but the differences were not statistically significant compared with that of before therapy(P>0.05).There was an increasing tendency in memory ability scores of Statin group,while the attention score with a downward tendency after treatment,but there was no significant change in the other subprojects,the differences were not statistically significant compared with that of before therapy(P>0.05).The scores of control group had a downward tendency in the language ability,while the scores of the visuospatial/executive function had an increasing tendency after treatment,but there was no significant change in the other subprojects,the differences were not statistically significant compared with that of before therapy(P>0.05).(4)ADL scale suggested that:After treatment,there was no change in the total score of ADL scale in each group,the differences were not statistically significant among the groups and the groups before and after treatment(P>0.05).(5)Inflammatory factors suggested that:Comparison between groups,the difference of IL-6 was not statistically significant between Xuezhikang group and Statin group before treatment(P>0.05).There was a statistical difference in IL-8 between Xuezhikang group and Statin group before treatment(P=0.045<0.05).The difference of IL-6 was not statistically significant between Xuezhikang group and Statin group after treatment(P>0.05).Within the group,after treatment,the IL-6,IL-8 of patients in Xuezhikang group and Statin group were both reduced,especially the IL-8 in Statin group was decreased most obviously,and the difference was statistically significant compared with that of before therapy(P=0.011<0.05),while the rest were not statistically significant compared with that of before therapy(P>0.05).(6)Blood fat showed that:The comparison between Xuezhikang group and Statin group of the LDL-C levels before treatment was not statistically significant(P>0.05).There was no statistically significant difference in LDL levels for the patients between Xuezhikang group and Statin group who were treated for three months(P>0.05).Within the group,the LDL-C levels in Xuezhikang group had no obvious change after treatment,but the difference was not statistically significant compared with that of before therapy(P>0.05);The patients in Statin group had a decline in LDL-C levels after treatment,but the difference was not statistically significant(P>0.05).(7)The safety analysis showed that:There were no abnormal changes in the blood routine,hepatic and renal function examination after three months of treatment of three groups compared with that of before therapy.There was one patient in Statin group with mild adverse events that was conscious of the muscle soreness in the lower limb,fatigue,can tolerate and no obvious abnormalities in liver function tests.There were no adverse events in Xuezhikang group and control group.Conclusion:Our results demonstrate that,there was no significant difference in the total integra before and after treatment in Xuezhikang capsules,while it has a tendency to improve memory function,especially in improving the language ability which has statistical difference,and the clinical efficacy is safe. |
PDF Full Text Request