The Influence Of Shenqi Soup On Inflammatory Cytokines And Myocardial Perfusion In Patients With ACS After PCI

ObjectiveTo explore the influence of Shenqi Soup on inflammatory cytokines and myocardial perfusion in patients with acute coronary syndrome(ACS)after percutaneous coronary intervention(PCI).Methods60 ACS patients meeting the grouping condition were selected,who hospitalized at the department of cardiology of Foshan Hospital of TCM from June 2015 to December 2016.They were randomly divided into Shenqi Soup group(30cases)and control group(30cases).Two groups were all treated by conventional western medicine treatment,and the Shenqi Soup group was treated by Shenqi Soup additionally.The level of Interleukins-6(IL-6)and hypersensitive c-reactive protein(hs-CRP)from serum will be detected in 15 minutes and 7 days after PCI.The score of traditional Chinese medicine(TCM)symptoms and Myocardial contrast echocardiography(MCE)will be detected in 24 hours and 4 weeks after PCI.All the data were built in a database,analyzed by spss 22.0,and index' s differences between the two groups were compared.Results1.The level of IL-6 and hs-CRP from serum of Shenqi Soup group and control group in 7 days after PCI were significantly higher than that in 15 minutes after PCI(P<0.05).The differences of the level of IL-6 and hs-CRP from serum between Shenqi Soup group and control group in 15 minutes after PCI were not significant(P>0.05).The level of IL-6 and hs-CRP from serum of Shenqi Soup group in 7 days after PCI were significantly lower than that of control group(P<0.05).2.The differences of the myocardial blood flow(MBF)supplied by normal coronary artery between Shenqi Soup group and control group in 24 hours and 4 weeks after PCI were all not significant(P>0.05).The MBF supplied by normal coronary artery of Shenqi Soup group and control group in 24 hours after PCI were not significantly different with that in4 weeks after PCI(P>0.05),3.The MBF supplied by sick coronary artery of Shenqi Soup group and control group in 4 weeks after PCI were significantly higher than that in 24 hours after PCI(P<0.05).The MBF supplied by sick coronary artery of Shenqi Soup group in 24 hours after PCI was not significantly different with that of control group(P>0.05).The MBF supplied by sick coronary artery of Shenqi Soup group in 4 weeks after PCI was significantly higher than that of control group(P<0.05).4.The score of TCM symptom of Shenqi Soup group and control group in 4 weeks after PCI were significantly lower than that in 24 hours after PCI(P<0.05),The score of TCM symptom of Shenqi Soup group in 24 hours after PCI was not significantly different with that of control group(P>0.05).The score of TCM symptom of Shenqi Soup group in 4 weeks after PCI was significantly lower than that of control group(P<0.05).5.On 4 weeks' observation,the overall efficiency of Shenqi Soup group is significantly better than that of control group(P<0.05).ConclusionPCI will damage blood vessels and increase its inflammatory response.However,Shenqi Soup can reduce vascular endothelial injury and promote endothelial repair after PCI by reducing the levels of serum IL-6 and hs-CRP,as well as inhibiting the inflammatory response.It also can improve the MPI of the area supplied by sick coronary artery and promote the recovery of the hear.What is more,Shenqi Soup can improve the score of TCM symptom and uncomfortable symptoms.Shenqi Soup is worth popularizing in clinic because of its brtter curative effect than the treatment only by western medicine.