The Effect Of The Compound Administration Of Ropivacaine And Magnesium Sulfate In Ultrasound-guided Quadratus Lumborum Block On Postoperative Analgesia Of Laparoscopic Gynecologic Surgery

Objective: To investigate the effect of the combined administration of ropivacaine and magnesium sulfate in ultrasound-guided quadratus lumborum block(QLB)on postoperative analgesia of laparoscopic gynecologic surgery.Methods: Ninety patients belonging to American Society of Anesthesiologists(ASA)physical status I or II,aged between 40 and 60 years,scheduled for laparoscopic gynecologic surgery were enrolled.They were randomly divided into ropivacaine group(group N),magnesium sulfate group(group M)and blank control group(group C).After induction,all the patients underwent ultrasound-guided bilateral QLB,patients in group N were treated with 0.375%ropivacaine 20 ml and normal saline 2ml on each side,group M was treated with0.375% ropivacaine 20ml+10% magnesium sulfate 2ml on each side,and group C was treated with normal saline 22 ml on each side.Patient-controlled intravenous analgesia(PCIA)was used in three groups.Visual analogue scale(VAS)at rest and during activity at 4,6,12,24 and 48 hours postoperatively,consumption of morphine,the time of first analgesic request,frequency of rescue analgesia,satisfaction with postoperative analgesia,and any side effects were recorded.Results: VAS scores in group M and group N were significantly lower than in group C at 4 and 6 h postoperatively(P < 0.001).And VAS scores were lower in group M at 12 and 24 h postoperatively compared to group N and group C(P <0.05).The mean total morphine consumption was significantly lower in group M than in group N and group C(P < 0.001).The mean time to the first PCIA bolus was significantly prolonged in group M compared to group C(P < 0.05).The satisfaction with postoperative analgesia of group M was superior to that of group N and group C(P<0.05).There was no significant difference in side effects among the three groups.Conclusion: Magnesium sulfate as an adjuvant to ropivacaine in ultrasound-guided QLB prolongs the duration of analgesia,decreased analgesic requirements and improving patient satisfaction without significant side effects.