The Predictive Value Of Serum ?-HCG Levels For Early Pregnancy Outcomes After Frozen Embryo Transfer

ObjectiveThe aim of the present study was to evaluate the predictive value of ED 15-20 serum ?-HCG levels as an early predictor for pregnancy outcomes after frozen embryo transfer.MethodsThis was a retrospective study including 1600 frozen cycles in our hospital.The pregnancy outcomes were divided into three groups:non-viable pregnancy,singleton live birth pregnancy and twin live birth pregnancy.We use t-test to determine whether there is statistical difference of serum P-HCG between different pregnancy outcomes.An ROC curve is used to establish the cut-off serum ?-HCG values for singleton live birth pregnancy and twin live birth pregnancy.Result1.The ED 15-20 serum ?-HCG levels were statistically higher in singleton live birth pregnancy and twin live birth pregnancy compared to non-viable pregnancy(P<0.001);The ED15-20 serum ?-HCG levels were statistically higher in twin live birth pregnancy than singleton live birth pregnancy.2.On ED 15 the Optimal cut-off value for singleton live birth pregnancy was 174.5IU/L(sensitivity:79.0%,specificity:84.6%,AUC:0.858);On ED16 the Optimal cut-off value for singleton live birth pregnancy was 216.5IU/L(sensitivity:84.7%,specificity:77.7%,AUC:0.881);On ED17 the Optimal cut-off value for singleton live birth pregnancy was 271.5IU/L(sensitivity:86.9%,specificity:78.9%,AUC:0.882);On ED 18 the Optimal cut-off value for singleton live birth pregnancy was 426IU/L(sensitivity:86.1%,specificity:77.0%,AUC:0.907);On ED 19 the Optimal cut-off value for singleton live birth pregnancy was 594IU(sensitivity:87.6%,specificity:83.3%,AUC:-0.911);On ED20 the Optimal cut-off value for singleton live birth pregnancy was 872IU/L(sensitivity:83.5%,specificity:86.6%,AUC:0.888);3.On ED 15 the optimal cut-off value for twin live birth pregnancy was 401.0IU/L(sensitivity:66.1%,specificity:71.4%,AUC:0.757);On ED16 the optimal cut-off value for twin live birth pregnancy was 603.5IU/L(sensitivity:81.5%,specificity:70.2%,AUC:0.836);On ED17 the optimal cut-off value for twin live birth pregnancy was 842.5IU/L,(sensitivity:77.6%,specificity:71.9%,AUC:0.818);On ED18 the optimal cut-off value for twin live birth pregnancy was 1251.0IU/L(sensitivity:74.5%,specificity:64.2%,AUC:0.777);On ED19 the optimal cut-off value for twin live birth pregnancy was 1876IU/L(sensitivity:80%,specificity:69.5%,AUC:0.817);On ED20 the optimal cut-off value for twin live birth pregnancy was 3186IU/L(sensitivity:82.6%,specificity:82.5%,AUC:0.894).Conclusion1.The ED 15-20 serum ?-HCG levels were statistically higher in singleton live birth pregnancy and twin live birth pregnancy compared to non-viable pregnancy(P<0.001);2.Optimal ED15-20 cut-off value for singleton live birth pregnancy was 594IU/L(sensitivity:87.6%,specificity:83.3%,AUC:0.911)on ED19.3.Optimal ED 15-20 cut-off value for twin live birth pregnancy was 3186IU/L(sensitivity:82.6%,specificity:82.5%,AUC:0.894)on ED20.4.ED15-20 Serum P-HCG levels can well predict singleton live birth pregnancy and twin live birth pregnancy after frozen embryo transfer,but it can predict the former better.