Association Study Of Single Nucleotide Polymorphisms Of SCN5A And HCN4 Genes And Sick Sinus Syndrome

Sick Sinus Syndrome(SSS) can occur in people of all ages, however the incidence of which is the most in senior population. The patients' lives and living quality are threatened by decreased cardiac input or brain blood vessel perfusion owing to arrhythmia such as sinus bradycardia, sinus atrial block, and sinus arrest. The mutation of SCN5A gene which encodes INa might lead to sinus bradycardia according to some studies, but the relation of SCN5 A single nucleotide polymorphism(SNP) and SSS has not been reported. As the difference of SNP exists in different population, the association of five SCN5A polymorphisms and SSS in Chinese Han population will be studied. The HCN4 gene of which encodes If channel is very important to cardiac pacemaker cell automaticity. The SSS might be caused by mutation of HCN4 gene. Therefore the other aim of our study is to discover SNPs of HCN4 exon 1, including the regulatory sequence and exon-intron boundary of it, which plays an importable role of channel function. Furthermore, we will analyze the association between SNPs discovered and SSS.Methods: A case-control design was applied in this study. A total of 140 unrelated hospitalized patients suffered from SSS were enrolled from Fuwai Hospital between August 2003 and May 2004, excluding those complicated with valvular heart disease, congenital heart disease,...