| Objectives:To investigate the prevalence of thyroid nodules(TN)and epidemiological characteristics in urban and rural residents of Jilin Province through the epidemiological survey,and to explore the influencing factors of TN.Methods:The stratified cluster random sampling method was used to select urban and rural permanent residents over 18 years in Jilin Province and to conduct a cross-sectional survey.Finally,2484 cases were included in the study,including 1163 cases of urban residents,accounting for 46.8%,1321 cases of rural residents,accounting for 53.2%.The participants completed questionnaire,physical examination,laboratory biochemical tests and thyroid ultrasound.The original data were input through Epidata software by two different person,the third person was responsible for checking,exporting data.The final data were analyzed by SPSS 17.0 software.Results:1?The prevalence of TN in urban and rural residents in Jilin Province was 608 cases,the overall prevalence rate was 24.5%,the standardized prevalence rate was27.0%;2,The prevalence of TN increased with increasing age,the trend test was statistically significant(P <0.001),OR: 1.035(1.023-1.045);3 ? The standardized prevalence rate of TN in female was 29.6%,in male was 23.9%.The prevalence of TN in female was higher than that of men(P <0.01),OR: 2.416(1.850-3.155);4 ?Compared with the group without TN,each thyroid diameter of the left and right lobes were larger in group with TN(P <0.05);5 ? TN were mainly for solid hypoechoic,less than 1cm solitary nodule,TN overall calcification rate was 23.7%;6?The prevalences of TN were statistically significant with different educational levels(P <0.001);Comparison between groups,the prevalence of TN was higher in the illiterate group than in the high school / secondary school group and the college /university group(P <0.05),and was higher in the primary school group than that in the high school / secondary school group and the college / university group(P<0.05);7 ? The prevalences of TN were statistically significant with different occupation(P <0.001);Comparison between groups,housework group was higher than other occupational group(P <0.05);8?Different salt levels were not associated with the prevalence of TN(P >0.05);9?The prevalence of TN in female smoking group was higher than that of non-smoking group(P <0.05);10?The prevalences of TN in different BMI groups were different(P <0.001),and the prevalences of TN were increased with the increasing of BMI grade,and the trend test was also statistically significant(P <0.001);11?With the increasing of waist circumference,the prevalence of TN increased(P <0.01),OR: 1.022(1.004-1.041);12 ? With the deterioration of glucose metabolism,the prevalence of TN increased(P <0.001),the trend test was statistically significant(P <0.001);and with the increasing of fasting blood glucose level,the prevalence of TN increased(P <0.001),OR: 1.144(1.014-1.290);13?The prevalences of TN in different urinary iodine concentration groups were different(P<0.05);Comparison between groups,the prevalence of TN in iodine excess group was lower than that of the other three groups(P <0.05).In different urinary iodine concentration groups,the prevalences of single nodules and multiple nodules were different(P <0.05),iodine deficiency group was mainly for multiple TN,in other groups were single TN;with the increasing of urinary iodine concentration,the prevalence of multiple TN decreased(P <0.05);14?The prevalence of TN increased in TPOAb positive group than negative group;15?With the increasing of systolic blood pressure,the prevalence of TN increased OR: 1.016(1.007-1.024).16?Multivariate regression analysis showed that women(OR: 2.416,95% CI: 1.850-3.155,P <0.001),age(OR: 0.034,95% CI: 1.023-1.045,P <0.001),family history of thyroid disease(OR: 1.014,95% CI: 1.014-1.280,P =0.021),FBG(OR: 1.144,95% CI:1.014-1.290,P =0.028),systolic blood pressure(OR: 1.016,95% CI: 1.007-1.024,P<0.001),waist circumference(OR: 1.022,95% CI: 1.004-1.041,P =0.018)were the independent risk factors for TN.Conclusion:1?The standardized prevalence rate of TN in urban and rural residents in Jilin Province was 27.0%.,in female was 29.6%,in male was 23.9%.The prevalence of TN in female was higher than that of men;2?Female,increased age,increased fasting blood glucose,elevated systolic blood pressure,increased waist circumference,thyroid disease family history were independent risk factors for TN;3 ? TN were mainly for solid hypoechoic,less than 1cm solitary nodule,TN overall calcification rate were 23.7%. |
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