| In 1978,the birth of the first test-tube baby in the world marked a milestone in the history of reproductive medicine.At present,human assisted reproductive technology birth of newborns accounted for 1% of the total number of 4%,the number has more than 500 million.A number of studies have confirmed that compared with spontaneous conception pregnancy,ART assisted reproductive technology to increase the maternal and child perinatal pregnancy outcome,but some studies have shown that ART adverse maternal and child perinatal outcome and maternal infertility factors are still controversial.Placenta as an important place for the physical exchange of the fetus and the mother,the formation and circulation of the microvascular network is the protection of the mother and child material exchange,for the maintenance of normal pregnancy is important.Studies have shown that ART technology significantly affects the intrauterine growth trajectory of human and animal,and ART technology on placental function and fetal intrauterine growth trajectory research concern.ObjectiveTo systematically review the maternal and fetal outcomes of patients in our center,and to further explore the effect of ART on maternal and child outcomes and placental morphology,and relationship with the age.Materials and Methods1.Objective: patients were select in Zhengzhou University Third Affiliated Hospital of Reproductive Medicine Center line IVF / ICSI-ET to help the treatment and delivery in our hospital from January 2012 to January 2016,925 cases;according to the year,2938 cases of spontaneous conception pregnancy were randomly selected.2.Methods:To compare the differences in age,gestational age,gestational age,gestational age,gestational age,gestational complications,and perinatal outcome and neonatal body mass,length,and placental weight.According to age,age group <35 years old group and age ?35 years old group,compared different age groups in ART group and SC group perinatal outcome,placental weight and neonatal weight relationship.3.Statistics approach:SPSS 21.0 statistical software for statistical analysis,measurement data using (?)±s said,count data using percentage description;measurement data comparison between the two groups using two independent samples Student's t-test,count data comparison of two groups of practical ?2 or continuity correction,Correlative factor analysis was performed using two-class Logistic analysis.P <0.05 for the difference was statistically significantResult1.Baseline baseline data: the two groups of patients age,pregnancy times,delivery and delivery of gestational age and other differences were statistically significant(P <0.05).There was no significant difference in the age of menarche and the increase of body weight during pregnancy(P> 0.05).Pregnancy combined with uterine scar was included in the second line of maternity analysis Logistic analysis [aOR: 1.122,95% CI(0.839-1.499)](P> 0.05).2.Maternal perinatal outcome: Age and maternity were included in the classification.Logstic analysis showed that ART group(5.0%)had a higher incidence of placenta previa than in the SC group(3.9%)[P = 0.023,aOR: 0.646,95% CI(0.443-0.942)].Two groups of hypertensive disorders in pregnancy,Gestational diabetes mellitus(GDM),Intrahepatic cholestasis of pregnancy(ICP),pregnancy with thyroid dysfunction,pregnancy with anemia,group B streptococcal infection and postpartum hemorrhage and other perinatal complications and complications were no significant difference(P> 0.05).3.Fetal development and neonatal situation: the incidence of neonatal severe asphyxia(6.7% vs 2.3%)and neonatal birth defects(1.7% vs 0.5%)were higher than those in the SP group(P <0.05).The weight of placenta was weight in ART group(590.44±96.77 g)than in the SP group(577.17±90.81 g),what's more,the placental efficiency was lower(P <0.05).There were no significant differences in Fetal growth restriction(FGR),neonatal sex,neonatal body weight,neonatal length and neonatal mortality in ART group and SP group(P?0.05).4.After age stratification,the maternal baseline data and perinatal outcome :(1)Age <35: ART group was older,and gestational age week was smaller than SP group(P <0.05).The average birth weight was lower,while the birth rate of neonatal severe asphyxia and neonatal birth defects were higher,and the placental efficiency was lower in ART group(P<0.05).(2)Age?35,the baseline data(such as : patients age and the increase of body weight)were no difference between the two group(P?0.05);ART group in oligohydramnios,placenta previa,neonatal body weight and placenta weight were higher than the SC group(P < 0.05);others were no difference(P?0.05).Conclusion1.The maternal perinatal outcome and neonatal outcome with ART is relatively safe.2.ART affects placental efficiency.3.With age increasing,Age had a predominant effect on maternal outcome,and the effect of ART was reduced. |
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