| Research purpose: Take treating through Danshu capsules as the control group to observe the clinical curative effect of treating chronic Cholecystitis Gallstones through the combination of Xiaoshilidan capsules with UDCA.Methods: Observe 82 cases of patients who had been diagnosed with Chronic Cholecystitis through abdominal color Doppler ultrasound and treated in the hepatobiliary medical department of Second Hospital of Jilin University from September,2014 to December,2016.All these cases are divided into 3 groups randomly.There are 27 cases in control group NO.1 in which the patients only take 3 Danshu capsules each time(3 times a day);There are 28 cases in control group NO.2 in which the patients only take 3 Xiaoshilidan Capsules each time(3 times a day);There are 27 cases in experimental group NO.3 in which the patients take 3 Xiaoshilidan Capsules and 750 mg of UDCA each time(1 times a day).There are 115 cases of patients who had been diagnosed with Chronic Cholecystitis gall-stone through abdominal color Doppler ultrasound.All these cases are divided into 4 groups randomly.The control group NO.3 consists of 25 cases,in which patients only take 750 mg of UDCA(1 times a day);the control group NO.4 consists of 30 cases,in which patients only take 3 Xiaoshilidan Capsules each time(3 times a day);the control group NO.5 consists of 27 cases,in which the patients take 2 Xiaoshilidan Capsules and 750 mg of UDCA each time(1 times a day);the experimental group NO.2 consists of 31 cases,in which the patients take 3 Xiaoshilidan Capsules and 750 mg of UDCA each time(1 times a day).The course of treatment for chronic Cholecystitis is 4 weeks,and the course of treatment for chronic Cholecystitis gallstone is 12 weeks.After 2 weeks of treatment,general improvement of symptoms of the chronic cholecystitis patients were examined and recorded,including right upper abdominal pain,mouth pain,back pain,the gallbladder area tenderness,abdominal distension after eating or dyspepsia etc.After 4 weeks of treatment,the general improvement of symptoms of the chronic cholecystitis gall-stone patients were examined and recorded,including right upper abdominal pain,mouth pain,back pain,the gallbladder area tenderness,abdominal distension after eating or dyspepsia etc.The dissolution status of gallstone in patients with chronic cholecystitis gallstones was respectively rerecorded at 4th and 12 th week after treatment.Results:1.After 2 weeks of treatment,the improvement status of these patients with chronic cholecystitis in experimental group was significantly better than that of control group,including the relief symptom of right upper abdominal pain,mouth pain,back pain,the gallbladder area tenderness,abdominal distension after eating or dyspepsia etc.,and the difference was statistically significant(P<0.05);the decrease of symptom score(average)after the treatment in experimental group is obviously better than the control group(P<0.01);the intra-group comparison shows that there is obvious difference in the decrease of symptom score(average)after treatment(P<0.01).2.After 4 weeks of treatment,the improvement status of these patients with chronic cholecystitis gall-stone in experimental group was significantly better than that of control group,including the relief symptom of right upper abdominal pain,mouth pain,the gallbladder area tenderness,abdominal distension after eating or dyspepsia etc.,and the difference was statistically significant(P<0.05);In terms of improvement status of back pain,the experimental group No.2 was better than the control group No.3 and control group NO.4,the difference was statistically significant(P<0.05);the experimental group No.2 was slightly better than the control group No.5,but the difference was not statistically significant(P > 0.05);the decrease of symptom score(average)after the treatment in experimental group is obviously better than the control group(P<0.01);the intra-group comparison shows that there is obvious difference in the decrease of symptom score(average)after treatment(P<0.01).3.As for patients with chronic cholecystitis gall-stone after 4 weeks of gall-stone dissolution therapy,the treatment efficiency of experimental group was 45.2% while the treatment efficiency of control group NO.3,control group NO.4 and control group NO.5 were respectively 16%,13.3% and 20.7%;after 12 weeks of gall-stone dissolution therapy,the treatment efficiency of experimental group was 87.1% while the treatment efficiency of control group NO.3,control group NO.4 and control group NO.5 were respectively 56%,53.3%,62.1%;there was a significant difference between the gall-stone dissolution therapy efficiency of experimental group compared with the control group(P<0.05).Conclusion:In terms of improving clinical symptoms,treating patients with chronic cholecystitis through combination of Xiaoshilidan capsules and UDCA is significantly better than only taking a single medication,and the treatment course of the combined therapy group was also significantly shorter than single medication group;Treating patients with chronic cholecystitis gall-stone through combination of Xiaoshilidan capsules and UDCA improves the clinical symptoms.What's more,the dissolution therapy is more effective and significantly better than the control group especially for the long course of 12 weeks.Therefore,the combination therapy of Xiaoshilidan capsules and UDCA is worthy applied in clinical treatment. |
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