The Investigation Between Ankle Brachial Index,C-reactive Protein And The Degree Of Coronary Heart Disease

BackgroundsCoronary atherosclerotic heart disease(referred to as coronary heart disease)is a serious threat to human life and health's major cardiovascular disease.It is the result of the development of atherosclerosis which caused organ damage and it is part of systemic disease.The development of atherosclerotic disease is a long process,so the early detection and identification of asymptomatic high-risk groups,intervention in subclinical vascular disease progression are the basic measures to delay and control of cardiovascular events.The ankle brachial index(ABI)is being used as an indicator of the degree of atherosclerosis and is playing an increasingly important role.C-reactive protein(CRP)is an important indicator of inflammatory activity and presence.In recent years,the study revealed that inflammation may be the initiation factor of the atherosclerosis process of coronary heart disease and C-reactive protein(CRP)is directly involved in the development of coronary heart disease,promoting the development of plaque inflammatory reaction,which is the strong predictor and risk factor of cardiovascular disease.ObjectiveIn this study,coronary artery angiography(CAG)was used to study the relationship between ABI and CRP levels and the degree of coronary artery disease.We aim to evaluate the correlation between the detection and coronary artery disease and investigate the value of early detection and disease monitoring..MethodsFrom February 15,2016 100 patients were selected from the First Affiliated Hospital of Zhengzhou University,Department of Cardiology who were diagnosed as Unstable angina pectoris.It ends at March 29,2016.The excluding criteria:rheumatic heart disease,secondary hypertension,acute Myocardial infarction,cancer,trauma,infection,diabetes,severe liver and kidney disease and immune disorders that may cause CRP rise.All patients underwent CAG.CHD diagnostic criteria:at least one coronary artery stenosis>50%.According to the results of SYNTAX,CHD group was divided into mild group(1-22),moderate group(23-32)and severe(>33)group.Using the SPSS 17.0 statistical software version.Counted data were using rate or percentage and compared with x2 test,while measuremented data were using mean±standard deviation and compared with the paired t test.If the P value is less than 0.05,the value is statistcally significant.Results1.There was no significant difference in age,sex,hypertension,LDL-C and triglyceride in each group(P>0.05).2.Compared with non-CHD group,the ABI value of CHD group was lower and the value of hs-CRP was higher,in which differences were statistically significant(P<0.05).3.Compared with the mild lesion group,the ABI value of the moderate and severe lesion group was lower(P<0.05).Compared with the moderate lesion group,the ABI value of the severe lesion group was lower(P<0.05).There was no significant difference in the value of hs-CRP between the three groups(P>0.05)ConclusionsCombined detection of ABI and hs-CRP have important practical value,which can provide a simple and effective census method for the high risk population of coronary heart disease.