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Study Of The Relationship Among Ankle-Brachial Index For Coronary Atherosclerotic Heart Disease

Posted on:2011-06-07Degree:MasterType:Thesis
Country:ChinaCandidate:F WeiFull Text:PDF
GTID:2144360305975789Subject:Surgery
Abstract/Summary:PDF Full Text Request
In recent years peripheral arterial stenosis and coronary stenosis of the incidence and mortality rates on the rise, about coronary and peripheral arterial relationships, for scholars have a large number of studies have shown that when patients have a history of coronary heart disease, and specifically of coronary artery stenoses more complicated peripheral arterial stenosis. In order to maximize the lower incidence of coronary heart disease, mortality rates improve life quality, it should be early detection of coronary stenosis and related interventions. Therefore early screening and intervention artery dysfunction is cardiovascular disease prevention and control of the "upstream", is to improve the level of cardiovascular disease prevention is key. Strengthening the artery disease screening and early detection, prevention and treatment of arteriosclerosis diseases have im-portant significance level. With imaging development, cardiac and periphe-ral vascular examination means greater capabilities, such as vascular ultrasound, MRA, CTA, DSA, blood vessels, more specific, however these checks require special equipment and specially trained operators, thus to some extent limited the these detection technology in hospitals in particular the application of basic hospital. Therefore, the development of a more simple and efficient detection technology has a very real significance. In recent years, with a series of new atherosclerosis disease detection tech-nology, the advent of a non-invasive means of detecting abnormal artery structure and function is becoming more and more attention. Some prospective clinical study results suggest that, through the ankle brachial index (ABI) Ankle-brachial index, can reflect the degree of arteriosclerosis. Foreign ankle brachial index (ABI) test is atherosclerotic disease screening of high-risk populations. State-of-the-art research shows low ABI and the severity of coronary heart disease. and so found the patients ABI<0.9, Severe lesions on coronary artery has predictive value. This topic to atherosclerosis systemic change is based on the characteristics of the ABI value and coronary stenosis.Purpose:using common desktop sphygmomanometers ABI numerical, to make a comparison of coronary angiography, evaluation of the ankle brachial index and coronary artery stenosis.Research methods:select the 2008-2009 period in affiliated chifeng Institute of Cardiology and cardiac surgery because of angina pectoris hospitalization parallel coronary angiography confirmed to 84 cases in patients with coronary heart disease. Which male 59 cases (70.23%), women's 25 patients (29.77%), average age (the age of 63±12). In contrast with resting before each pisonic in 10 minutes using ordinary desktop sphygmomanometers bilateral ankle brachial artery and arterial blood pressure, blood pressure measurement, three consecutive days, average. ABI measurement using AHA recommended methods, unilateral ABI of the lateral malleolus artery (that is, the posterior tibial artery or dorsalis pedis artery) systolic blood pressure and bilateral brachial artery systolic pressure of highest value ratio, finally taking sides ABI as a low value of the patients of ABI for statistical analysis. At the same time, and recorded with include common conditions such as gender, age, confirmed the stroke, diabetes mellitus (DM), high blood pressure (HBP), Hyperlipidemia (HL), a history of smoking, and family history of heart and brain and blood glucose (Glu), total cholesterol (TC), low density lipoprotein (LDL), high density lipopro-tein (HDL), triglyceride (TG) and urea nitrogen (BUN) and creatinine (CRE),uric acid(UA),high-sensitivity C-reactive protein (hsCRP), Fibrino-gen (FIB) and laboratory measurements. According to the results of coronary angiography patients are divided into normal group, single lesions group, the second branch of the lesions groups, three diseases Group (including the left main disease). Normal group is defined as one of the major blood vessels (left anterior descending coronary artery, circumflex branch, and its main branch the right coronary artery stenosis) in 50% or stenosis; single lesions is defined as a single major artery stenosis in more than 50%; two in group is defined as two main stenosis are above 50%; three diseases group defined as three main artery stenosis are above 50% or left main coronary artery stenosis in more than 50%. Uses the Gensini method on the results of quantitative analysis, contrast with this assessment of the extent of the coronary artery disease. Each evaluation of ABI and coronary artery stenosis dependencies, specificity and sensitivity, evaluation of ABI and coronary artery stenosis.Results:'normal group 17 patients (20.2%), normal ABI mean 1.08±0.16, coronary artery disease score of 1.29±0.46; single lesions group 18 patients (21.4%), single lesions group ABI average of 1.07±0.19, coronary artery disease score of 13.1±8.54; two in Group 17 patients (20.2%), the two diseases group ABI average of 0.92±0.24, coronary artery disease score of 28.90±11.42; 32 cases of severe disease Group (38.1%), severe lesions group ABI 0.82±0.37, coronary artery disease score of 44.01±13.75. Among them, the two diseases group ABI below normal group, there are significant differences, p<0.05。explanations of ABI lower on disease no predictive value, but the two teams, and serious diseases have predictive value. Further analysis shows, ABI≤0.9 is the prediction of severe coronary artery disease, the best truncation, its sensitivity to 31.45%, specificity of 94.78%. With this result, we see the ABI as a non-invasive, easy, affordable, operation duplicates better clinical examinations have clinical application, on the severity of the arterial lesions have a better predictive value, and has good specificity and to ordinary sphygmomanometers ABI is better suited in patients with severe for screening CAD, early intervention and treatment.
Keywords/Search Tags:ankle brachial index, coronary artery disease, coronary angiography
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