Clinical Observation On Qinghao Biejia Decoction In The Treatment Of Prurigo Nodularis

Objective:This study is to observe the efficacy of Qinghao Biejia Decoction combined with NB-UVB in the treatment of prurigo nodularis.The control group treated with Qinghao Biejia Decoction alone,respectively.Methods:The patients with prurigo nodularis from dermatology department of Jiangsu province of hospital TCM.According to the criteria of the study,a total of 36 patients were divided into treatment group and control group.There are 18 cases in each group.The treatment group received Qinghao Biejia Decoction combined with NB-UVB.Taking methods of Chinese medicine daily 1 agent,a total of 500ml divided into two parts after half an hour after dinner.We conducted the NB-UVB two times per week and the initial dose of 0.5J/cm2.If the irradiation site had no erythema or only mild reaction,then increase the original dose of 20%.Otherwise maintaining the original dose.The control group treated with Qinghao Biejia Decoction.The treatment methods were the same as in the treatment group.Patients in each group were given"Da Feng Zi Ding" 3 times a day,which made by Jiangsu province of hospital TCM.All the patients were recorded the general conditions,PIP,Visual Analogue Scale(VAS),DLQI in the second week,fourth week and eighth week,respectively.In the end,statistical analysis was performed using the corresponding statistical methods.Results:In the second week,fourth week and eighth week,respectively,the comprehensive score comparison in the two groups.The patients of two groups with clinical symptoms were improved(P<0.05).In the second week,comparison between the two groups,there revealed no significant difference between the two groups(P>0.05).There was no significant difference between the two groups.In the fourth week and eighth week,there exist significant statistical difference(P<0.05).The overall score of the treatment group was better than that the control group.After treatment the DLQI of the two groups have significant difference(P<0.05).All the DLQI were improved between the two groups.In the eighth week the treatment group compared to the control group,there revealed significant difference(P<0.05).The DLQI of the treatment group improved significantly than the control group.After 8 weeks of the treatment,the total effective rate of the treatment group was 88.8%, and the control group was 77.8%.The treatment group compared to the control group,there revealed significant difference(P<0.05),indicating that comprehensive effect of the treatment group was better than the control group.Conclusion:Qinghao Biejia Decoction alone and Qinghao Biejia Decoction combined with narrow-band ultraviolet(NB-UVB)have a better effect and safe in the treatment of prurigo nodularis.Qinghao Biejia decoction combined with narrow-band ultraviolet(NB-UVB)can reduce the side effect of NB-UVB.It is a safety and effective method for the treatment of prurigo nodularis and worthy of clinical application.