The Clinical Research Of Supplemented Qingxin Zishen Decotion Combined Lipitor Treatment On Disharmoney Between Heart-Kidney Of Menopausal Syndrome Combined Dyslipidemia

Objective:By observing the effects of supplemented Qingxin Zishen Decotion combined lipitor on clinical symptoms,endocrine and blood lipid level of patients with disharmony between heart and kidney of menopausal syndrome combined dyslipidemia,study on the decoction in improving clinical syndromes,regulating endocrine disturbance and metabolism of blood lipid,and intervention effect and possible mechanism preliminarily.Thus providing strong evidence that Chinese Medicine can treat and prevent disturbance of blood lipid and cardiovascular disease which both related to menopausal syndrome.Methods:Patients with disharmony between heart and kidney of menopausal syndrome combined dyslipidemia were recruited according to the diagnostic criteria in department of gynaecology and cardiology of Jiangsu Province Hospital of TCM between January,2016 and March,2017 and randomly divided into the treatment group treated with supplemented Qingxin Zishen Decotion and Lipitor and the control group treated only with Lipitor.Before treatment,assessing the general condition and clinical symptoms,and finishing laboratory testing(estradiol(E2),luteinizing hormone(LH),follicle-stimulating hormone(FSH),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),and low density lipoprotein(LDL-C)).After 12 weeks treatment,assessing general the condition and clinical symptoms,and finishing the same laboratory testing again.In the end,the control group,2 cases were lost and fall off and 2 cases of removing due to lack of steroid sex hormone test.Ultimately,44 cases were employed,24 cases in treatment group,20 cases in control group.Results:(1)In aspect of improving clinical symptoms:after 12 weeks,in treatment group,the quantitative and qualitative evaluation of clinical symptoms were improved(P<0.05).In control group,apart from frequency and degree of sweat were improved(P<0.05),the rest quantitative and qualitative symptoms had no significant difference(P>0.05),and Kupperman scores were in the rising trend(P<0.05).12 weekends later,there was statistically difference in quantitative and qualitative clinical symptoms between two groups(P<0.05).The clinical symptoms of treatment group was obviously lighter than the control group(P<0.05).(2)In aspect of regulating endocrine disturbance:after 12 weeks,in treatment group,the levels of serum FSH,LH were decreased(P<0.05)and serum E2 level was unchanged(P>0.05).In control group,the levels of serum FSH and LH were unchanged(P>0.05)and serum E2 level was decreased(P<0.05).12 weekends later,there was statistically difference in serum FSH level(P<0.01)and no difference in serum LH,E2 levels between two groups(P>0.05).(3)In aspect of improving blood lipid metabolism:after 12 weeks,under the condition of no changes in dietary assessment scores,the levels of blood TC,LDL-C were significantly decreased(P<0.01)in both group.In addition,blood TG level was decreased and blood HDL-C level was improved in treatment group(P<0.05),while blood TG,HDL-C levels remained unchanged in control group(P>0.05).12 weekends later,there was statistically difference in blood TC,TG,LDL-C,HDL-C levels between two groups(P<0.05),and blood lipid levels in treatment group were better than the control group.(4)In aspect of laboratory effect:The total effective rate of treatment group in improving blood lipid was 100%,while the control group was 80%.There was statistically difference in improving blood lipid between two groups(P<0.05),and the effect of treatment group was better than that of control group.(5)In aspect of clinical effect:in treatment group,control rate was 29.2%,apparent rate was 70.8%,effective and non-effective rate were both 0%,and the total effective rate was 100%.In control group,control rate,apparent rate and effective rate were both 0%,non-effective rate was 100%,and the total effective rate was 0%.There was statistically difference in clinical effect between two groups(P<0.01),and effect of treatment group was better than that of control group.(6)Exploring the correlation of endocrine disturbance and dyslipidemia:before treatment,the higher the FSH levels of patients',the higher the TC and LDL-C levels.12 weeks later,in treatment group,the more lower the serum FSH level,the more lower the blood TC and LDL-C levels(P<0.05).However,there was no obvious correlation between serum FSH level and blood TG,HDL levels(P>0.05).Conclusion:Supplemented Qingxin Zishen Decotion can obviously improve clinical symptoms of patients with disharmony between heart and kidney of menopausal syndrome,lower serum FSH and LH levels,keep the level of serum E2.And what is more,the decotion not only enhanced the effect of lipitor lowering blood TC and LDL-C levers,but also lowered blood TG lever and increased blood HDL-C lever,which effects the control group did not have.12 weeks ago,patients' FSH level was positively correlated with their TC and LDL-C level.12 weeks later,the blood TC and LDL-C levers of treatment group positively correlated serum FSH lever.Preliminary supposition:supplemented Qingxin Zishen Decotion reaches the role of regulating the metabolism of blood lipid by improving the function of Hypothalamic-pituitary-ovarian axis and delaying ovarian consenescence.