Trends In Gynecologic Malignant Tumors Received In Specialist Women's Hospital In Recent 10 Years

Background:As diseases whose morbidity and mortality are relative high among malignant tumors,gynecologic malignancies are drawing more and more attention.However,reports on gynecologic malignancy condition and trends in China are still insufficient.This research aims to analyzing the clinical information of patients who were diagnosed with gynecologic malignancies and treated in our hospital during 2006-2015.Through studying the trends of patients' age,staging,histological type and so on during the 10 years,we gain more necessary data supports for learning about the prevention and control of the diseases and further improvements of the current treatment strategies.Methods:We reviewed 6340 patients with gynecologic malignancies firstly diagnosed and treated in our hospital from Jan.2006 to Dec.2015.And we studied their data on time of first diagnosis,patients' age,site of tumors,histologic type,staging and so on,and compared their 10 year trends with other existent data.The gynecologic malignant tumors we mentioned here include cervical cancer,endometrial cancer,ovarian malignant cancer,gestational trophoblastic neoplasia(GTN),uterine sarcoma,vulvar carcinoma,vaginal cancer,fallopian tube cancer,and other types.Results:We collected 6340 gynecologic malignancy patients diagnosed and treated in our hospital during 2006-2015.Cervical cancer(2837,44.7%),endometrial cancer(1419,22.4%),ovarian malignant tumors(1205,19.0%)and GTN(624,9.8%)had the largest amount of patients.Cervical cancer patients increased greatly in recent 10 years,while endometrial cancer and ovarian malignant tumor patients' number also had an increasing trends in recent 5 years.1)Cervical cancer:Susceptible age was 40-49 years old,40-49,50-59,60-69 year old cases all increased.The rate of early cervical cancer(Stage I,Stage II)ranged from 97.8%?99.6%,and the ratio of cervical squamous cell carcinoma and adenocarcinoma kept the same for the whole period.2)Endometrial cancer:Most of the endometrial cancer patients were of 50-59 years old.Case number grew from 86(6.1%)in 2010 to 222(25.7%)in 2015;The ratio of 60-69 years old patients increased in recent 4 years;Stage I patients accounted for larger proportion of the total,grew from 67.6%(2006)to 83.7%(2015),Stage ??Stage ??Stage ?declined(p<0.01);Adenocarcinoma was the most common histologic type for endometrial cancer,among which endometrioid cancer accounted for 95.0%.And clear cell carcinoma took 1.3%of the total.3)Ovarian cancer:Its case number grew from 106(21.4%)in 2006 to 178(20.7%)in 2015;Most epithelial ovarian malignancy patients were 50-59 years old,non-epithelial ovarian malignancy patients were younger.Among all the histologic types,epithelial tumor was most common.Different from some other areas,the number of Stage ? ovarian malignancy patients(48.4%)went over Stage ?'s(38.0%)in our hospital,and the gap grew larger during the 10 years,as Stage? proportion decreased during the 10 years and Stage ? proportion increased in the recent 4 years,presenting a decreasing stage generally(p<0.01).Epithelial malignancy was the same,while non-epithelial malignancy had lower staging.In older patients,we saw fewer Stage I and more Stage ?.4)Gestational trophoblastic tumors:51.6%of the patients were among 20-29 years old,and age showed no fluctuation during the 10 years.Most patients were diagnosed Stage ?(64.2%).Among 624 gestational trophoblastic Tumor patients,we found 7 Placental Site Trophoblastic tumor(PSTT)and 7 Epithelial Trophoblastic Tumor(ETT).Conclusions:1.In all the gynecologic malignancy cases reviewed in our hospital in recent 10 years,cervical cancer,endometrial cancer,ovarian malignancy and GTN account for the largest proportion.2.In recent 10 years cervical cancer and endometrial cancer cases increased distinctly in our hospital,among which cervical cancer patients of 40-49 years old,50-59 years old and 60-69 years old increased obviously,and endometrial cancer patients of 60-69 years old increased as well in recent 4 years.3.Our hospital is a vital domestic medical center for GTN treatment.