The Clinical Observation Study About Shugan Qi And Qingre Li Dan On The Content Of Glycoprotein In Bile Of Patients With Choledocholithiasis

Common bile duct stones are clinical common disease,the main treatment of the disease for surgery,the purpose is to lift the obstruction,remove the lesion,smooth drainage.As a result of various factors,there is still a high recurrence rate after surgery,how to reduce the recurrence rate of postoperative stones is a problem faced by clinicians.Traditional Chinese medicine in abdominal surgery,including biliary tract surgery in the perioperative treatment of the exact effect,such as the treatment of postoperative gastrointestinal function recovery,postoperative fatigue syndrome,etc.,has been widely used.Shugan qi,heat and gallbladder from the theory of liver and spleen related to the theoretical basis,from the perspective of Chinese medicine,for the disease pathogenesis,through the overall concept,from the macro aspects of regulation of the body.It has been pointed out that glycoprotein is a combination of protein,is an important component of bile.In the formation of stones,glycoproteins play a role in promoting the nucleus,and bile in the mucus fusion,the other insoluble calcium salt particles together,after the package precipitation,and ultimately lead to the formation of stones.From the perspective of modern medicine,Shugan gallbladder,heat and dampness method can adjust the micro-internal environment,so as to achieve liver protection,regulation of bile secretion and reduce the chance of stone formation opportunities.ObjectiveTo observe the effect of Shugan qi and Qingre Li Dan method on biliary glycoprotein in patients with common bile duct stones,and to further explore the mechanism of Shugan qi and Qingre Li Dan in preventing recurrence of common bile duct stones.Through the clinical efficacy of the relevant quantitative indicators of support,more scientific guidance of patients with choledocholithiasis after clinical treatment.Methods1.Experimental design:randomized controlled single-blind trial method,will be consistent with laparoscopic choledocholithotomy.Forty patients were divided into experimental group and blank control group.The experimental group consisted of Sini Powder as the base prescription,plus Chenchen,Gardenia,Bupleurum,Citrus aurantium,lOg of Radix Paeoniae Alba,Glycyrrhiza 5g,Chen 15g,Gardenia 10g),with the clinical addition and subtraction,a daily dose,Shui jianbi.Blank control group:not traditional Chinese medicine or Western medicine treatment.2.Record the subject general information(gender,age,surgery)and perioperative related data(WBC,NEUT,ALT,AST,TBIL,Cr,PT,the first day after surgery,heart rate,body temperature,T tube bile drainage).The bile drainage volume and bile glycoprotein content of T tube were observed continuously before and after the first and fourth weeks after the administration of Chinese medicine.3.Through the general information on the subjects,perioperative related information,postoperative records of T tube bile drainage volume,biliary glycoprotein content of the statistics,the use of SPSS21.0 medical statistics software and Office Excel2013 software for data analysis and processing.Results1.The general data(gender,age)and the general condition of the two groups were statistically analyzed Sexual differences(P>0.05);Two groups of patients in the perioperative period did not see death,cardiovascular and anesthesia accidents.No lungs after surgery Department of infection,biliary fistula and other related complications.2.The WBC,NEUT,ALT,AST,TBIL,Cr,PT were compared between the two groups before and after operation.(P>0.05).There was no significant difference between the two groups(P>0.05).3.The two groups after the first day of the body temperature,heart rate,T tube drainage volume measurement,the statistical analysis,the results in There was no statistically significant difference(P>0.05).4.There was no significant difference in the daily drainage volume of T-tube between the two groups Sexual differences(P>0.05).5.There was no significant difference in the determination of biliary glycoprotein in the treatment group before treatment and the control group(P>0.05),comparable.Compared with the control group,the total mean value of bile glycoprotein content in the first week,the second week,the third week and the fourth week after treatment was significantly different(P<0.01).6.Compared with before treatment,the experimental group after treatment for the first week,the second week,the third week,the fourth week of bile glycoprotein.There were significant differences in the mean values of white content(P<0.01).ConclusionShugan qi,heat and gallbladder method of bile duct stones in patients with biliary glycoprotein content has a certain impact,can reduce the content of bile glycoprotein.