Study Of Pathogenic Factorsm, Diagnosis, Pathogenesis Of Primary Pathological Duodenogastric Reflux And Protective Effect Of Qingre Liqi Granules On Gastric Mucosa

Part One The clinical study of pathogenic factors in primary pathological duodenogastric refluxObjective:To study the relationship among the gastric mucosal lesions caused by primary pathological DGR, the Hp infection, the bile reflux and the alkali reflux assessed with synchronously monitoring 24 hour intragastric pH and bilirubin absorbance.Methods:1 Subjects:43 cases in primary pathological DGR group, 25 males, 18 females, age from 21-year-old to 63-year-old. All cases were enrolled with established criteria.2 24 hour intragastric bile reflux and pH were measured using Bilitec 2000 and pH monitor synchronously. Time percentage of bilirubin absorbance≥0.25 and time percentage of pH≥4 were used as threshold to evaluate the severity of duodenogastric reflux. Endoscopy and gastric mucosa biopsies were performed in all cases for examination with rapid urease test, improved Giemsa staining and HE staining in order to diagnose Hp infection and define the lesions of gastric mucosa. The degree of chronic inflammation, activity, atrophy, intestinal metaplasia of gastric mucosa were observed according to the New Sydney system criteria. The lesions of gastric mucosa were classified into four degrees, which were normal, mild, moderate, and severe, scored as 0, 1, 2, 3. The total scores of gastric mucosal lesions degree were taken as New Sydney system pathological scores. The pathological Dixon scores of gastric mucosa was adopted simultaneously.Results:1 All cases were divided into two groups, Hp positive group(14 cases) and...