The Study Of The Correlation Of Serum Neuron-specific Enolase In Diabetic Retinopathy

Background/Objectives:Diabetic microvascular complications include diabetic peripheral neuropathy(DPN),diabetic retinopathy(DR)and diabetic nephropathy(DN),where DR is not only the most common microvascular complication of diabetes,but also major cause of non-traumatic adult blindness.DR is irreversible,it is extremely important to early detection,early diagnosis and early treatment.At present the diagnosis of DR mainly have color fundus photography,fundus fluorescein angiography and optical coherence tomography,and so on.There is no effective biological indicator for early diagnosis of DR.At home and abroad has been a lot of research on neuron-specific enolase(NSE)as independent risk factors for DPN,may become the biological index of early diagnosis of DPN.Foreign countries have reported serum NSE level in patients with diabetic retinopathy is closely related to DR,but there is no such report in China.To this end,this study investigated the correlation between serum level of NSE and DR,trying to provide reference for early diagnosis.Methods:137 cases of type 1 and 2 diabetes patients who were admitted to the Department of Endocrinology or Ophthalmology in Yangzhou University Clinical Hospital from September 2015 to June 2016 were selected as study subjects,including 87males and 50 females.All patients underwent the examination of fundus color photograph and were divided into two groups based on the results:1.diabetic retinopathy group(DR group),a total of 110 cases,of which 74 cases of male and 36 cases of female,the average of(55.18±13.73)years;2.non diabetic retinopathy group(NDR group),a total of 27 cases,of which 13 cases of male and 14 cases of female,the average of(56.70 ± 10.07)years.The basic information of the subjects were collected including gender,age,course of disease,body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP).Venous blood was collected and biochemical indexes of the subjects were measured including NSE,glyoohemoglobinAlc(HBA1c),urinary microalbumin(UMA),fasting blood glucose(FBG),blood urea nitrogen(BUN),serum creatinine(Scr),triglycefide(TG),total cholesterol(TC),high-density lipoproteincholesterol(HDL-C)low-density lipoproteincholesterol(LDL-C).The data were processed by SPSS21.0 and Medcalc(v15.6)software.Result:No significant difference(p>0.05)was found between DR gruop(n=110)and NDR group(n=27)regarding 14 basic aspects below:gender,age,course of disease,BMI,SBP,HBAlc,UMA,FBG,BUN,Scr,TG,TC,HDL-C and LDL-C.Compared with the NDR group,the serum NSE level of the DR group were significant higher than those of the NDR group;the DBP level of the NDR group were significant higher than those of the DR group.Binary Logistic Regression analysis showed that the serum NSE levels were closely correlated to DR(OR=1.248,95%CI:1.070?1.457,P=0.005)after sex,age,glucose metabolism indexes,duration were excluded.The optimal cutoff point of serum NSE levels to distinguish patients whih diabetic retinopathy from those without was 12.31 ?mol/L,with a sensitivity of 69.09%and a specificity of 59.26%.Conclusion:The significant increases in serum NSE levels in DR patients may be an independent factor of DR and may be a potential biomarker of DR.The detection of serum NSE levels may be one of the methods for predicting and early diagnosis of DR.