Study Of The Relationship Between Serum Level Of Neuron-specific Enolase And Diabetic Peripheral Neuropathy In Type 2 Diabetes Patients

Objectives The purpose is to observe the type 2 diabetes(T2DM) serum neuron-specific enolase(NSE) levels to explore with diabetic peripheral neuropathy(DPN) correlation.for providing the theoretical basis for prevention and treatment of DPN.Methods According to 1999 WHO diabetes diagnosis and classification criteria selected North China United University of Science and Technology Affiliated Hospital 2013.1-2014.8 Endocrinology hospitalized patients with type 2 diabetes, 106 cases, male 57 cases, female 49 cases, the age range of 28 to 80 years, mean age 54.50 ± 10.63 years.According to the diagnostic criteria for diabetes DPN are screened into two groups, the DM group 56 patients(30males and 26 females, age range 28 to 80 years, mean age 53.73±9.76 years), 50 cases of DPN group(male 27 cases,23 females, age range 31 to 79 years, mean age 55.36±11.57years). According to the TCSS score with the DPN group was divided into mild DPN group;moderate DPN group; severe DPN group; All subjects than 12 h fasting, morning venous blood serum triglyceride(TG), High density lipoproteincholesterol(HDL-C), low-density lipoprotein-cholesterol(LDL-C),total cholesterol(TC),glycated hemoglobin A1C(Hb A1c), fasting plasma glucose(FPG), serum neuronspecific enolase(NSE) levels.All data analysis applications IBM SPSS19.0 statistical software package for statistical analysis, measurement data were presented as mean±standard deviation( x ±s);the pairwise comparisons using T-test for independent samples;Among groups by x2-test;between multiple sets of data were compared using ANOVA. Correlation between indicators using Pearson correlation analysis and correlation coefficient. Risk factors for DPN using multivariate Logistic regression analysis.Results 1 DPN group and DM group sex composition by χ2 test showed no significant difference described in this study constitutes gender comparable.DPN group and DM age group,(P>0.05).2 DPN group compared with the DM group course, DPN group than in DM group(P<0.05).3.DPN group BMI, SPB, DBP, LDL-C, FPG, Hb A1 c, TC, TG, higher than DM group,(P<0.05).4.DPN group HDL-C levels below the DM group,(P <0.05).5.DPN group serum NSE level higher than the diabetic group, with the DPN severity increased significantly,(P<0.05).6.DM group, more than 12 cases of serum NSE 13 ug / L, DPN group of more than 27 cases of patients with serum NSE 13 ug / L, by χ2 test OR=4.3, described above the normal range of serum NSE, diabetic patients with DPN 3.3-fold increased risk.7. DPN group compared with the single pure diabetic group NCV, ulnar nerve, median nerve, peroneal nerve, tibial nerve MCV and ulnar nerve, median nerve, sural nerve SCV slowing significantly(P<0.05).8.serum NSE levels in diabetic patients from low to high interquartile grouping. With the increase of serum NSE levelssignificantly slower nerve conduction velocity,(P<0.05).9.In a merger of DPN as the dependent variable, with various clinical parameters as independent variables, Multiple factor non conditional Logistic regression analysis showed that DPN was positively correlated with the course of disease, TG,LDL-C,BMI, SBP, DBP, Hb A1 c and serum NSE(P<0.05).10.Performed Pearson correlation analysis showed that NSE levels and LDL-C,TG,Hb A1 c,duration,FPG was positively correlated(r=0.654, 0.899,0.599,0.852, 0.535) and age,sex no gender-related.Conclusions 1 diabetic peripheral neuropathy patients with higher serum NSE level of patients with diabetes alone and increase the degree of DPN increased significantly.2 Nerve conduction velocity decreased, increased serum NSE levels.3 Correlation between serum NSE andcourse of disease, LDL-C, TG, Hb A1 C, FPG positive.