Epidemiological And Clinical Analysis Of Group A Rotavirus Infection In Hospitalized Children With Diarrhea

Objective To investigate the prevalence of group A rotavirus(RV)infection in hospitalized children with acute diarrhea under 5 years of age,and to analyze the clinical features of RV infection,so as to understand the characteristics of RV infection more deeply,and to provide basic data for formulating the strategy of prevention and treatment.Methods The information of children with diarrhea who were under five years old were collected from 2014 to 2015 in our hospital,and the colloidal gold method was used to detect the fecal rotavirus antigen.Investigation and analysis was performed for RV infection status of different months?age groups?genders.The children with diarrhea is divided into RV positive group and RV negative group according to the results of RV.And the clinical features of two groups,including diarrhea?vomiting?dehydration?fever?nervous system damage?respiratory tract infection?severity and laboratory test results,including lactate dehydrogenase(LDH)?creatine kinase(CK)?creatine kinase isoenzyme(CK-MB)? aspartate transaminase(AST)? alanine transaminase(ALT)were compared and analyzed.Results(1)301 cases were detected positively in the 850 specimens,and the positive rate was 35.41%.RV infectious diarrhea could be onset in the whole year,but the peak was 10-12 months.RV infection rates between different age groups were significantly different(?2=80.993,P<0.05),Age-specific incidence of RV infection was higher in 12-18 months of age(53.91%).In brief,265(88%)cases children with RV were less than 18 months old.RV infection rates of different genders had no significant difference(?2=0.375,P<0.05).(2)Hospitalized children with diarrhea in RV positive group were more prone to watery stool(?2=14.570,P<0.001)?severe diarrhea(?2=5.931,P<0.05)?vomiting(?2=66.093,P<0.001)?dehydration(?2=45.003,P<0.001)?respiratory tract infection(?2= 11.829,P < 0.05)than in RV negative group,the difference was statistically significant.(3)Children with RV infectious diarrhea showed higher Vesikari score than non RV infected diarrhea,the difference was statistically significant(t=4.937,P<0.001).The incidence of severe diarrhea in children with RV positive diarrhea group was higher than that in RV negative diarrhea group,the difference was statistically significant(?2=21.430,P<0.001).(4)LDH?CK?CK-MB?AST and ALT of RV positive group were significantly higher than RV negative group,the difference was statistically significant(LDH: t=4.105,P<0.001;CK: t=2.060,P < 0.05;CK-MB: t=5.463,P<0.001;AST: t=3.423,P<0.05;ALT:t=4.339,P<0.001).Conclusion(1)RV infection is an important cause of diarrhea in children under 5years old.RV infection peak occurre in the dry and cold seasons;A statistically significant association can be found between the RV status and the different age groups.(2)There is an association between RV and the occurrence of watery diarrhea ? severe diarrhea ? vomiting and extraintestinal symptoms such as dehydration?respiratory tract infection.(3)The clinical manifestations of diarrhea disease with RV infection are more severe than those without RV infection.(4)RV infection has a certain degree of influence on myocardium and liver.We should strengthen the prevention and treatment of RV infection.