Postoperative Olfactory Function Comparison Of Pituitary Adenoma Resection Via Endoscopic And Microscopic Transsphenoidal Approach

Purpose This study was designed to investigate the effects of postoperative olfactory function of pituitary adenoma resection by endoscopic and microscopic transsphenoidal approach.Methods The patients who were received treatments in the First Affiliated Hospital of Anhui Medical University were accepted into this non-randomized controlled study from June 2015 to June 2016.All patients’ olfactory function were evaluated by Five Sniffing Solution before surgery,1 week and 1 month after surgery.Statistical methods include t-test,variance analysis and chi-square test.P<0.05 means statistically significant difference.Result 45 cases were treated in this study.31 patients were finally included in the analysis.15 cases were underwent endoscopic transsphenoidal approach(group Ⅰ).And16 cases were underwent microscopic transsphenoidal approach(group Ⅱ).There was no statistically significant difference of preoperative olfactory recognition threshold for each solution.All patients’ olfactory function declined or even disappeared 1 week after surgery when compared to pre-operation.The average smell recognition threshold were4.59±0.32 and 4.59 ±0.31.The average smell recognition threshold were 3.19 ±0.40 and2.76 ±0.36 1 month after surgery.The olfactory abnormal rate of group II was lower than those in group I(6.25% and 40%,p<0.05).Conclusion Both endoscopic and microscope transsphenoidal approach for pituitary adenoma resection have a short-term impact on subjective olfactory function.microscope transsphenoidal approach may be more superior to endoscopic transsphenoidal approach on early postoperative recovery.