| Objectives:to evaluate the differences of olfactory functions,nasal related symptoms and quality of life with olfactory tests,scales and questionnaires in patients underwent two approaches of endoscopic assistant pituitary adenoma resections,and to explore the effects of two methods of endoscopic assistant pituitary adenoma resections on olfactory functions,nasal related symptoms and quality of life.Methods:Patients records with pituitary adenoma admitted in our hospital during November,2016 to November 2017 were collected.Patients who underwent endoscopic.transseptaltranssphenoidal approach were assigned to observation group while those who underwent endoscopic transnasal transsphenoidal approach were assigned to control group.In this study,a well-reported way was used to test olfactory function;the sino-nasal outcome test-20(SNOT-20)was used to evaluate nasal symptoms while the MOS item short from health survey(SF-36)was used to evaluate the quality of life.Olfactory functions and SNOT-20 scales were measured at pre-operation and 1,3 and 6 months after the operation.SF-36 were measured at 1,3 and 6 months after the operation.Analysis of variance was used to process the data above with the assistance of SPSS 19.0 software.Results:150 patients were enrolled in observation group,including 60 male and 90 female respectively,with average age of 44.47±10.81 patients were enrolled in control group,including 36 male and 45 female,with average age of 46.20±12.65.Statistic results show:①olfactory test results:within the observation or control group,all the patients suffered a significant decline in olfactory functions at 1 month after operations;average olfactory function still significantly decreased at 3 and 6 months after operations.Comparing the control group,there was no significant difference in olfactory threshold in the observation group before operation while there were significant difference at 3 and 6 months after operations.②SNOT-20 scales:there were the symptoms of rhionrrhea,cough,dizziness and fatigues at 1 month after operation in control group and observation group.The symptoms above recovered instently at 3 months after operation.Specifically the dimensions of sleep dysfunction and nasal symptoms fully recovered in observation group compared to the pre-operation situation,however,only the dimension of sleep dysfunction recovered in control group.There was not significant difference in nasal symptoms between the two groups at 6 months after operation.③SF-36 scales:there were no significant differences in all dimensions of SF-36 scales between the two groups 3 and 6 month after operation.Only one dimension in the scale,the physical functioning,was significantly different between the two groups 3 month after operation..Conclusions:(1)Olfactory function test,SNOT-20 and SF-36 can be used to evaluate olfactory function,nasal symptoms and quality of life in patients underwent endoscopic pituitary resction.(2)Patients underwent either endoscopic transseptal transsphenoidal approach or endoscopic transnasal transsphenoidal approach will suffer from decreased olfactory function and the function cannot recover to normal 6 month after operations.However,the endoscopic transnasal transsphenoidal approach has relatively less impact on the patients’ olfactory functions.(3)Both approaches can induce increased nasal symptoms,which can recover to normal level 6 months after operation.In comparisons,Patients underwentendoscopic transseptal transsphenoidal approach recover faster compared those underwent endoscopic transnasal transsphenoidal approach.(4)The quality of life in the two groups was recoved to the preoperative level at 6 months after the operation.Patients underwent either approaches have relatively the same quality of life. |
