Meta Analysis Of The Treatment Of Primary Biliary Cirrhosis (Cholangitis) With Combination Of TCM And Western Medicine

Objective: Chinese medicine has certain effect in treatment of primary biliary cirrhosis(PBC),but is still in the exploratory stage,lacking systematic standards and evidence-based basis.Integration of small sample clinical trials by Meta analysis,so as to enlarge the sample size,and then draw more reliable conclusions,providing a reference for Chinese medicine treatment of PBC.Methods: We searched the Medline,Embase,Pubmed,Cochrane,Library,VIP,Wanfang,CNKI Chinese,online database of traditional Chinese medicine,and collected papers which included randomized controlled trials of traditional Chinese medicine or traditional Chinese and Western medicine treatment of PBC.Two researchers independently screened the literature,assessed the quality and extracted the information,and then used the modified Jadad scale to evaluate the quality of the literature.The effective rate,liver function,liver fibrosis index and immune index were selected as the therapeutic index.The data were analyzed by Rev Man5.3 software,the odds ratio(OR)and 95% confidence intervals(CI)were used to represent the two classification countdata,weighted mean difference(WMD)and 95% confidence interval(CI)were used to represent the continuous measurement data.Results: 39 papers which met the requirements were included,totally 2434 samples,4 papers of high quality and 35 papers of high quality;the control group were given Ursodeoxycholic acid(UDCA)treatment as the control condition,the experimental group were treated with the decoction of Chinese medicine or traditional Chinese medicine treatment on the basis of the control group;Meta analysis results showed that there was significant difference between the experimental group and the control group in efficiency,liver function,liver fibrosis index and immune index of Ig M,Ig G,but there was no significant difference in immunological indexes of AMA-M2.Conclusion: UDCA still plays an important role in treatment of PBC;Chinese medicine treatment of PBC is nothing but to Fuzhengquxie as the fundamental treatment,with Fuzheng nourishing the liver and kidney,Qi and blood,to Quxie eliminating dampness and heat,activating blood circulation,regulating liver qi;combination of traditional Chinese and Western medicine treatment of PBC has more advantages than the simple use of Western medicine in increasing the efficiency,improving liver function,hepatic fibrosis index and some immune indexes.