Relationship Between Traditional Chinese Medicine Constitution,SH2B3 Polymorphism And Response To Ursodeoxycholic Acid In Patients With Primary Biliary Cholangitis

Objective To explore the distribution of Traditional Chinese Medicine（TCM）constitution in patients with primary biliary cholangitis（PBC）,to explore the relationship between the major TCM constitution,SH2B3 polymorphism and response to ursodeoxycholic acid（UDCA）in patients with PBC.Methods 1.Seventy eight patients with PBC who treated with standardized therapy of UDCA longer than 1 year were enrolled from December 2019 to December 2021 in Hangzhou Xixi Hospital.2.The TCM constitution of patients with PBC enrolled was recognized,and the TCM constitution distribution was observed.3.The rs11065904T/A genotype of SH2B3 in patients with PBC enrolled was detected.4.The liver function indexes of the patients enrolled at the first diagnosis and after treating with standardized therapy of UDCA（13～15mg kg-1·d-1）longer than 1 year were recorded,and whether the patients respond completely to UDCA according to the Paris Ⅱstandard was evaluated.5.The relationship between the major TCM constitution,SH2B3 polymorphism and response to UDCA in patients with PBC was analyzed.Results 1.The rate of responsing completely to UDCA in the group of AA of rs11065904T/A was 57.6%,which was 36.4%in the group of TA and 75.0%in the group of TT.There was significant difference between the response to UDCA and the rs11065904T/A polymorphism in patients with PBC（P<0.05）.2.There were 22 cases of qi deficiency constitution（28.20%）,17 cases of qi stagnation constitution（21.70%）,10 cases of yin deficiency constitution（12.82%）,9 cases of balanced constitution（11.54%）,8 cases of blood stasis constitution（10.26%）,5 cases of yang deficiency constitution（6.41%）,5 cases of dampness-heat constitution（6.41%）,2 cases of phlegm-dampness constitution（2.56%）,and 0 case of inherited special constitution（0.00%）.3.The rate of responsing completely to UDCA was 31.8%in the group of qi deficiency constitution,which was 58.9%in the group of non-qi deficiency constitution.There was significant difference between the response to UDCA and the TCM constitution in patients with PBC（P<0.05）.4.Qi deficiency constitution group showed the rate of TA,AA and TT in rs11065904T/A were 50.0%,36.4%and 13.6%.Which were 39.3%,44.6%and 16.1%in the non-qi deficiency constitution group.There was no significant difference between the rs11065904T/A polymorphism and the TCM constitution in patients with PBC（P>0.05）.Conclusion The common constitutions of patients with PBC are qi deficiency constitution,qi stagnation constitution and yin deficiency constitution,of which qi deficiency constitution is the maj or constitution.TCM constitution and SH2B3 rs11065904T/A polymorphism in patients with PBC affect the response to UDCA.TA of rs11065904T/A and qi deficiency constitution are not conducive to the response to UDCA.The relationship between TCM constitution and polymorphism still needs further study.