Comparison Of Analgesic Effect Of Oxycodone And Sufentanil On Laparoscopic Radical Resection Of Colorectal Cancer In The Elderly

Objective To investigate the effects of oxycodone and sufentanil on analgesia after radical resection of colorectal cancer in the elderly.To explore the effect of the two drugs on postoperative intravenous analgesia.Methods 80 patients with senile colorectal cancer who underwent laparoscopic radical surgery were divided into group A and group B,with 40 patients in each group.All patients were selected for general anesthesia for anesthesia.Preoperative use of sedative drugs,in general anesthesia induction,the use of 1.5-2 mg/kg propofol,3-5μg/kg fentanyl,0.1-0.12 mg/kg vecuronium three drugs,In order to achieve a better anesthetic effect.And in the operation,with a micro-pump injection of remifentanil 0.3 ug/(kg.min)and propofol 4-12 mg/(kg.h),intermittent addition of vecuronium,continuous inhalation of heptasil Elderly patients maintain anesthesia.Mechanical ventilation tidal volume set to 10 ml/kg,respiratory rate of 15 to 20 times/min,suction ratio of 1:2,monitoring the end of breath carbon dioxide partial pressure(PETC02),to maintain PETC02 in 35～45 mmg.(0.07 mg/kg)with atropine(0.2～0.4 mg)as a muscle relaxant to antagonize the residual muscle relaxation(P<0.05),and the patients were treated with propofol and remifentanil.Role,after the patient into the anesthesia awakening room,all patients are in the wake of the room to remove the tracheal tube.Until the patient is completely awake and no oxygen in the oxygen saturation can still be greater than 95%more than 5 minutes before returning to the treatment area.A group of oxycodone hydrochloride 30 mg;group B sufentanil 100 ug,were dissolved in 100 ml of azizatroxon sodium chloride injection(azithromycin 10 mg),continuous pumping dose of 2 per hour M1,a single PAC compression dose of 2 ml,locking time of 15 minutes,analgesic time of 48h.The VAS score of the two groups was observed at different time points after the two groups(T0,2h for T1 and 4h for T2,12h for T3 and 24h for T4),and the Ramsay sedation score was satisfactory and statistically recorded within 48 hours Automated analgesic pump additional key actual,effective number of presses,the incidence of adverse reactions.Results According to the comparison between the two groups,it was found that the VAS score of group A was significantly higher than that of group B at T0-T2,the difference was statistically significant(P<0.05)T3,T4 could achieve satisfactory sedation effect;T1-T4(P<0.05).There was a significant difference between the two groups(P>0.05).There was no significant difference between the two groups(P>0.05).There was no significant difference between the two groups(P>0.05).Conclusion:There were fewer symptoms of nausea and vomiting and lethargy,but there were more significant differences in the number of effective presses than those in group B(P<0.05).In summary,oxycodone and sufentanil can achieve better postoperative analgesic effect.Conclusion Oxycodone and sufentanil for senile colorectal cancer after laparoscopic radical resection is safe and effective,sufentanil less adverse reactions,suitable for clinical applications.