Analyze The Analepsia Quality And Postoperative Analgesic Effects Of The Oxycodone And Sufentanil,Tromethamine In Radical Gastrectomy Patients With Stomach Carcinoma

Objective:To analyze the effects of oxycodone,sufentanil and tromethamine on analepsia quality and postoperative analgesic in radical gastrectomy patients with stomach carcinoma.Methods:One hundred and sixty patients who undergone radical gastrectomy(D2)were randomly divided into control group(group C,n=40),tromethamine group(group T,n=40),sufentanil group(group S n=40)and oxycodone group(group O,n=40).30 minutes before finishing operation,3ml physiological saline,0.5mg/kg tromethamine,0.1?g/kg sufentanil and 0.1mg/kg oxycodone were injected to every group respectively.PCIA was launched immediately when the Steward awakening score reached to 6 points.The Prince-Henry score,SpO2,RR,PaO2,PaCO2 at T1(when patients were sent into PACU),T2(when patients were observed 15 min),T3(patients left PACU with Steward awakening score reaching to 6 points)and the time that needed to reach T3,the numbers of drowsiness,dysphoria,respiratory depression,and unorientation in the PACU were analyzed.The VAS score at 2h,6h,12h,24h and 48h,the first press-time of PCIA,accumulative press times and doses during 24h and the numbers of analgesic remedy,dizziness,drowsiness,nausea,vomiting and the itch of skin post-operation were analyzed.Results:In the control group,there were highest Prince-Henry scores at T1,T2 and T3;Time needed to reach T3 was the longest;The incidences of dysphoria and adverse reactions were the highest;The RR was faster,PaO2 was lower and PaCO2 was higher(P<0.05).Compared with the T and S groups,the time needed to reach T3 was the shortest and the incidence of adverse reactions was the lowest in the O group(P<0.05).Compared with the T group,the Prince-Henry score at T1,T2,T3 and the incidence of dysphoria were less in the O group(P<0.05).Compared with the S group,the RR,PaO2 and PaCO2 in the O group were statistically different(P<0.05),but the Prince-Henry score at T1,T2,T3 and the incidences of dysphoria and respiratory depression in the PACU were no statistical differences between S and O groups(P>0.05).The VAS score at every time point in the ward were no statistical differences among the four groups(P>0.05).In the control group,the first press time of PCIA was earliest;The 24h-accumulative press times and 24h-accumulative dosage of analgesics were the most;the incidence of nausea and vomiting was the highest(P<0.05);The number of analgesic remedy was the most.Compared with the T and S groups,the first press time of PCIA was the latest in the O group;The 24h-accumulative press times and 24h-accumulative dosage of analgesics were the least in the O group;The incidence of adverse reactions was the lowest in the O group(P<0.05).Conclusion:Oxycodone was injected 30 minutes before finishing operation in radical gastrectomy patients with stomach carcinoma,which would provide fine analgesic effects,as well as better analepsia quality and less complication.