A Clinical Study Of Acupuncture For Chronic Fatigue Syndrome Patients With Cognitive Impairment Based On Event Related Potentials

Objective:Chronic fatigue syndrome (CFS) patients in this study,using the Chalder Fatigue Scale,Checklist for Individual Strength,and Somatic and Psychological Health Report,event-related potentials (ERP) to study acupuncture for Chronic Fatigue Syndrome patients with impaired cognitive function effect and possible mechanisms.Methods:38 patients with CFS were randomly divided into an acupuncture treatment group (group A) and comfort acupuncture group (group B).group A has 17 patients and group B has 21 patients.Streitberger needles are used in group A on Baihui(DU20),Ganshu(BL19),Shenshu(BL23),Zusanli(ST36),Shenmen(HT7).Streitbe rger placebo needles are used in group B on non-acupoints. All patients at the first and second weeks are treatment five times a week, the third and fourth weeks three times,there are total 16 times as a session. Respectively, at baseline and after 4 weeks of treatment,use the Chalder Fatigue Scale,Checklist for Individual Strength,and Somatic and Psychological Health Report to evaluate the clinical effects of acupuncture on fatigue and cognitive function., after 3 months follow-up evaluation of the long-term effects.18 cases of CFS patients and 12 healthy persons are detected ERPs by oddball paradigm with PVSAT,.PVSAT's reaction time, accuracy, loss and error rates are used to evaluate memory,attention of CFS. N2,P3's amplitude and latency to explore the extent of damage in information processing;At the baseline and four weeks later,group A and group B are compared to seek the acupuncture's in CFS cognitive impairment.Results:1.After 4 weeks of treatment,both group A and group B Chalder fatigue scale score are significantly decreased(P<0.05),group A decreased more than group B(P<0.05).After treatment 3 month follow-up, two groups score increased, the difference has statistically significant (P> 0.05).2.After 4 weeks of treatment, groups A and B's CIS and SPHERE score decreased significantly (P<0.05), A group score lower than group B, but the difference was not statistically significant (P> 0.05).3.Compared with healthy people,CFS patients has no significant difference on reaction time,accuracy, loss and error rates(P>0.05);CFS patients F7 electrode N2 latency is significantly longer than that in healthy people(P<0.05);CFS patients show no difference on P3 latency and amplitude(P>0.05).4.After 4 weeks of treatment,both group A and group B's reaction time are shorter(P>0.05),group A is shorter than group B but no significant difference.There is no significant difference in error and loss rate(P>0.05). Group A's N21atency decreased significantly(P<0.05),however group B's N2 latency increased significantly on F3,C3,C4,Fz,FCl,FC2 and FCz electrode(P<0.05).Group B's N2 latency is longer than group A(P<0.05).Both group A and group B's amplitude decreases on F3,FC2 electrode,the others increase but no statistically difference(P>0.05).Group A's amplitude decreases more than group B on F3 electrode(P<0.05).Group A's P300 latency decreases on F4,C4,F7,F8,Cz,FCl,FC2 electrode,group B's P300 latency increases on F3,F4,C4,F7,F8,Fz,Cz,FCl,FC2 electrode,but have no significant statistically difference(P>0.05),group A's P300 latency decreases on Cz and Fz electrode campared with group B(P<0.05).GroupA's P300 amplitude reduced while group B's P300 amplitude increases on all electrode(P>0.05),and the group A change of P300 amplitude is smaller than group B(P>0.05).Conclusion:1.Compared with the placebo acupuncture,true acupuncture treatment can effectively reduce fatigue from mental and physical aspects.Reduce reduce sleepy,work,sensation,heavy physical fatigue;alleviate mood change,unhappiness or depression mental fatigue.This therapy has the trend of enhance attention,motivation and activity.2.When CFS patients perform cognitive tasks.the left frontal region process slow down,the central region shows insufficient resource mobilization.Compared with placebo acupuncture,true acupuncture can speed up the left side of the central,bilateral frontoparietal region process,reduce the left frontal region,bilateral frontoparietal region mobilization of resources when working memory updates.