| Objective:Chronic Fatigue Syndrome (CFS) was officially named by Centers for Disease Control and Prevention(CDC) of the U.S government in 1988. It belongs to subhealth in modern medicine. The incidence of CFS rises year after year, which causes enormous economic losses. CDC forecasts that, CFS will become a key issue damaged the human being' s health in the 21st century. At Present, there are no effective methods for treating CFS because of its unclear etiology and pathogenesis. So it belongs to the dominant diseases of Traditional Chinese Medicine(TeM). As a non-pharmacological therapy, with its good therapeutic effect and non-toxic and non-sideeffect characteristic, acupuncture and moxibustion has great predominance on treating CFS. In recent years, many clinical reports illustrated that.On the basis of the clinical efficiency of treating CFS by acupuncture, combining with the pathogenesis of CFS, TCM and western medicine theory, reading a great quantity research of antiquity and modern literature, according to random control principle, and then choose the modern examination to carry out the acupuncture experimental research. The objective of our research is to perfect the CFS model, choose the effective therapy and discuss the possible way through which acupuncture has good effect in treating CFS.Methods:SD rats(male, weight 190-220g)were randomly distributed to normal control group, model group, acupuncture group and panaxoside group. It was through a combined stress factors with chronic constraint, swimming in the cold water and to obtain the CFS model. Normal control group wasn't given any methods. Acupuncture group was acupunctured in bilateralis Baihui, Shenshu, Zusanli alternatively;panaxoside group was given intragastric administration with panaxoside fluid. One month later, observing the behavior changes of the rats; and examining the content of the IFN-γ, TGF-βin serum and the monoamine neural substance in the hypothalamus and pituitary of the rats.Results:l. At the beginning of experiment, there were no significant differences between the groups. Later, compared with normal control group, the model rats appeared physical strength declining, the slowly increased weight(P＜0.01), obviously decreased activitities of rats in open-field test(P＜0.01) and tail hanging test(P＜0.05).Acupuncture and panaxoside fluid could improve the behavioral disorder and markedly reverse the fatigue states of the model rats.2. There were some metabolic disorders of monoamine neural substances. Compared with normal control group, there were obviously increase of the content of NE(P＜0.01),decrease of the content of 5-HT(P＜0.01) in the hypothalamus and pituitary in model rats. Compared with model group, there were decrease of the content of NE(P＜0.05),increase of the content of 5-HT(P＜0.05) in acupuncture group and panaxoside group.3. Compared with normal control group, there were obviously decreased IFN-γ(P＜0.01) and increased TGF-β(P＜0.05) in serum in model rats. Acupuncture and panaxoside fluid could increase the levels of IFN-γ(P＜0.01)and decrease TGF-β(P＜0.05).Conclusions:1. This text indicated that the model rats induced by complex stressers are succeded in simulating the pathogenesis and clinical manifestations of CFS.2. Acupuncture could markedly reverse the physical fatigue and the mental fatigue of the model rats, improve the fatigue states of the animals through psychosomatic regulation, and have the function of antifatigue and antistreSS.3. By decreasing the content of NE, increasing the content of 5-HT in the hypothalamus and pituitary and increasing the content of IFN-γ, decreasing the content of TGF-βin serum of the model rats may be one of the effective mechanisms of acupuncture.
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