Relationship Among Hip Circumference,Cardiovascular And Cerebrovascular Risk Factors And Cardiovascular Events In Patients With Type 2 Diabetes

ObjectiveTo comprehensively evaluate the relationship among hip circumference(Hip),cardiovascular and cerebrovascular risk factors and cardiovascular events(CVD)in adult patients with type 2 diabetes.MethodsUsing cluster sampling method,Type 2 diabetes(T2DM)patientswere selected according to the world health organization(WHO)diagnostic criteria based on the diabetes management information system(DIMS)database of our hospital,and the data of related investigation,physical measurement and biochemical testing were complete.Patients were divided into 4 groups according to the metabolic syndrome(MS)components,with only T2 DM component or T2 DM with other components(hypertension,hyperlipidemia,overweight or obese).Patients were divided into 4 groups by hip circumference quartiles(<91cm,91~<96cm,96~<101cm,?101cm).Results8771 subjects(539 men,999 women;30-98 years old,mean age: 64±11 years old;male: 4687,53%;female: 4084,47%)with T2 DM.Total group in T2 DM patients,except for total cholesterol(TC)and low density lipoprotein(LDL)and diabetes history no statistical difference between different hip level group(P>0.05),age,body mass index(BMI),waist circumference(WC),waist/hip ratio(WHR),hypertension(HTN),systolic blood pressure(SBP),diastolic blood pressure(DBP),triglyceride(TG),high density lipoprotein(HDL),metabolic syndrome(MS)and cardiovascular and cerebrovascular diseases(CVD)and family history of cardiovascular morbidity family history of hypertension prevalence rate with the increasing of the hip have been gradually increasing trend,had significant differences among different groups of the Hip(P<0.01).See similar trends in different subgroups.Multi-factor unconditioned Logistic regression analysis showed that the risk of developing metabolic diseases increased with Hip levels.After adjusting for age,gender,BMI,for different HC groups divided by quartiles(Hip<91cm,91cm?Hip<96cm,96cm?Hip<101cm,Hip?101cm),the OR(95% CI)were respectively described as follows:MS(2.23,95% CI:1.81-2.73),CVD(1.44,95% CI:1.11-1.86),HTN(1.93,95% CI:1.58-2.36),BMI 43.37(38.28-51.83)and central obesity(37.7,95% CI:29.18-48.63).There was a significant difference among groups(P<0.05).After adjusting for age,gender,BMI and WC,compared with T2 DM without any other components,the OR for T2 DM with different MS components and the corresponding dose-dependent relationshipwere respectively described as follows: T2 DM with 1 MS component(1.16,1.37,1.74;?~2=14.09,P<0.01);T2DM with 2 MS components(1.09,1.14,1.82;?~2=30.66,P<0.01);T2DM with 3 MS components(0.93,1.48,1.54;?~2=8.07,P<0.01).DiscussionBigger hip circumference is an independent risk factor for metabolic diseases in type 2 diabetic patients.