A Study On Effects Of Metabolic Syndrome And Type 2 Diabetes Mellitus To Metabolism Of Bones

Object To investigate whether there exist effects of metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) to metabolism of bones. Methods All the 239 subjects were divided into 3 groups (86 for MS group, 131 for T2DM and 89 for control, respectively). Of the patients, there were 67 were diagnosed suffering from MS as well as T2DM. Relations between such factors as age, body weight, body mass index, lumbar circuit, waist-hip ratio, body fat, body lean, glycosylated hemoglobin Alc, fasting insulin, HOMA insulin resistance index, insulin sensitivity index, osteocalcin and BMD, BMC,CBMC were investigated within the patients in groups of MS and T2DM. Biochemistry measurements, body weight, body fat, body lean and bone mass were compared between members of control group and patients in group MS and T2DM, respectively. Result (1)bone mass was correlated positive with body lean, body fat and negative with the fat content of total body and age, in the patients of MS group (P=0.000). (2) bone mass was correlated positive with body weight, body fat and ISI, and negative with the fat content of total body, HbA1c and age, in the patients of T2DM(P=0.000). (3) Such measurements as body weight, body lean, body fat, BMD, BMC, were higher, and CBMC were lower, in patients of MS group that that in members of control group (P<0.01) . (4) There was no significantly difference between the bone mass of patients in T2DM group and that of controls (P>0.05) . (5)Within the T2DM group, measurements of BMD, BMC were highest in obesity subgroup, then the overweight subgroup and lowest in normal subgroup(P<0.05). Measurements of CMBC were highest in the normal subgroup, lowest in obesity subgroup. overweight subgroup were in the middle (P<0.05) . (6) There was no significantly difference to be found, when the measurements of BMD, BMC and CBMC were compared between groups of T2DM and controls, matched for BMI (P>0. 05). Conclusion (1)Measurements of BMD and BMC were higher in MS patients, and the ratio of body fat was higher too, the latter might be reduce the CBMC of MS patients, so risks of OP and fracture might not be lower in the MS patients, than that in normal controls. (2) There was no significant effect of T2DM to bone mass. But, the bone-turnover-ratio might be increased in T2DM, so the bone mass might lost more, if the blood glucose was controlled not well for a long time or the weight loss was obvious . (3) bone mass was positively correlated to body lean and body fat. It was very important to rise up the ratio of body lean, in the prevention of osteoporosis . Probability of OP might be higher in persons with low body weight and low body fat. (4) There was no significant effect of insulin resistance to bone mass in the MS patients, to the patients of T2DM, bone mass might be increased if insulin sensitivity to be increased.