| Objective: To investigate the spleen wet removal as the theoretica l basis of the spleen and skin powder in the treatment of the clinical c urative effect of spleen deficiency wefness type infantile eczema,and th e results are compared with the commonly used clinical infantile eczem a treatment,so as to provide reference and basis for clinical treatment of spleen deficiency wefness type infantile eczema.Methods: 90 cases of children with eczema in department of Der matology of the First Affiliated Hospital of Guangxi College of traditio nal Chinese medicine were randomly divided into basic treatment group,Jian Pi Zhi Yang powder group(J group for short)and Shen Ling B ai Shu powder group(S group for short)three groups,and 30 cases i n each group.The basic treatment group treat with oral loratadine,S gr oup was given oral loratadine and Jian Pi Zhi Yang powder,S group was given oral loratadine and Shen Ling Bai Shu powder.The treatmen t lasted for four weeks and the curative effect of improvement of skin lesions,itching symptoms,changes in traditional Chinese medicine(TCM)syndrome in each group was observed and compared in 14 days,28 d ays after treatment.Results:(1)in the 14 th days after treatment,the efficiency of thr ee groups were 60%,70% and 66.67% in turn,and there was no signifi cant difference in three groups(?~2=0.689,P=0.709);in the 28 th days aft er treatment,the efficiency were 66.67%,93.33% and 83.33% in turn,and there had significantly differences(?~2=7.107,P=0.029).(2)the area of skin lesions after treatment in the three groups were significantly improved compared with before;in the 14 th days of treat ment,there was no significant difference in three groups(F=2.253,P=0.112);in the 28 th days of treatment,there was statistically significant di fference between the three groups(F=12.492,P<0.001),comparison bet ween three groups of each two groups,the difference was also statistic ally significant.(3)the EASI scores of the three groups after treatment were signif icantly lower than those before treatment;at the 14 th days of treatment,there were statistically significant differences between the three groups(F=3.732,P=0.028);in the 28 th days of treatment,there was statistically significant difference between the three groups(F=9.864,P<0.001),co mparison between three groups of each two groups,the difference was also statistically significant.(4)the pruritus scores of the three groups after treatment were sig nificantly lower than those before treatment;in the 14 th days of treatme nt,there was no significant difference in three groups(F=0.023,P=0.983);in the 28 th days of treatment,there was statistically significant diffe rence between the three groups(F=9.071,P<0.001),comparison between three groups of each two groups,the difference was also statistically si gnificant.(5)the scores of TCM symptoms of the three groups after treatme nt were significantly lower than those before treatment;in the 14 th days of treatment,there was no significant difference in three groups(F=0.023,P=0.983);in the 28 th days of treatment,there was statistically signifi cant difference between the three groups(F=9.071,P<0.001),comparison between three groups of each two groups,the difference was also statistically significant.(6)3 months after the end of treatment,the recurrence rate of the three groups were 57.14%,7.14% and 30%,and the difference was stat istically significant(?~2=6.229,P=0.044),the recurrence rate of J group was significantly lower than that of the basic treatment group and S g roup;6 months after the end of treatment,the recurrence rate of the th ree groups were 71.43% 14.29% and 50%,the difference between group s was also statistically significant(?~2=7.216,P=0.027),the recurrence rat e of J group was significantly lower than that of the basic treatment group and S group.Conclusion: J group was better than other two groups in improve ment children with skin lesions,skin itching and symptoms of tradition al Chinese medicine comprehensive,at the same time,it has less adverse reaction and low recurrence rate,so J group has good clinical efficacy,and it is a reliable method for clinical treatment of infantile eczema,worthy of clinical popularization and application. |
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