Implantable Venous Access Port-related Infection:Analysis Of Its Risk Factors

Objective: To study the risk factors of catheter-related infections in patients receiving implantable venous access port and to provide a scientific basis for clinical reduction of complications associated with catheter-related infections.Methods: A total of 582 patients,who received implantable venous access port at authors' hospital during the period from January 2012 to December 2015,(concerning their gender,age,tumor classification,score of the Eastern Cooperative Oncology Group,special treatment,history of medication and whether reside or not)were included in this study.The general clinical data,bacteriological data,disease progression and the incidence of implantable venous access port-related infections were retrospectively analyzed and all of these data was statistically analyzed by means of a software called SPSS17.0.Analysis of single factor(T-test and chi-square test and Fisher's exact test)and multi-factors were used into the analysis of possible risk factors,such as age,gender,category of patient(included hospital and clinic implanted),puncture,scoring of the Eastern Cooperative Oncology Group,tumor type,and chemotherapy regimens(include palliative and radical regimens)of complications of infection.Results: In the 582 patients,14 patients with infection symptoms were removed from the implantable venous access port,so the infection rate was 2.4% and the incidence rate of the implantable venous access port-related infection was 0.067 cases / 1000 catheter-days,the incidence of catheter-related infection was 0.116 per 1000 catheter days for hematologic malignancy and 0.061 per 1000 catheter days for solid organ malignancy.In the 48 patients with hematological malignancies there were 3 patients extubated infusion port,by contrast in the 534 patients of solid organ malignancies there were 11,as a result the infectionrate of patients with hematological malignancy was higher than that of patients with solid organ malignancy(6.3% vs.2.1%,P = 0.040).Univariable analysis showed that the infection rate was higher in the hospitalized patients(P=0.016),in the patients with hematologic malignancy(P =0.040),and in the patients receiving palliative chemotherapy(P=0.022).Multivariate binary logistic regression analysis indicated that the adjusted OR values for infection rate in patients with hematologic malignancy were 7.769(P=0.001),and the adjusted OR values for infection rate in patients receiving palliative chemotherapy were 4.863(P=0.003),respectively.Positive bacteria culture was confirmed in 9 patients,and the most causative organisms were staphylococcus(n=4)and candida(n=2).Conclusion:In this study,The underlying hematologic malignancy and the use of palliative chemotherapy in patients with implantable venous access port associated with the high risk of infections,maybe the independent risk factors for implantable venous access port-related infections.