| Background:Colorectal cancer(CRC)is one of the most common malignancy all over the world, the incidence and prevalence are keeping increasing by year. CRC is characterized by poor prognosis and high mortality rate when diagnosed in advanced stage. It is generally considered that circumstance, diet,life-style and genetic factor contribute to the development of CRC. More and more studies have revealed that there exist certain correlation between metabolic syndrome(MS) and CRC.Objective:To investigate the impact of metabolic syndrome and its components on the clinic-pathological characteristics of synchronous colorectal cancer by reviewing patients history.Methods:All CRC inpatients at Shanghai Rui Jin Hospital from January 1st2012 to December 31st2013 were collected and database was created. Patients with incomplete information were ruled out. The database contain basic information of patients demographic characteristics, initial symptoms, medical history,family history, combine MS and/or its components, endoscopic reports, imaging diagnosis, histopathologic diagnosis and metastasis status. According to the diagnostic criteria of MS proposed by CDS, patients were divided into two groups, MS group and non-MS group. Furthermore, the patients in non-MS groupwere subdivided into four subgroups according to MS components for further investigation: diabetes mellitus(DM) and non-DM, hypertension and non-hypertension, fatty liver and non-fatty liver, BMI?25kg/m2 and BMI<25kg/m2.The impact of metabolic syndrome and its components on clinicopathological characteristics of synchronous CRC were analyzed.Statistical software SPSS19 was applied.Results:1.According to the diagnostic criteria of MS proposed by CDS, 53 patients satisfied the criteria among 1092 patients included in the current study.There was a significant difference in age structure among MS group and non-MS group(p=0.022), the number of patients older than 60 in MS group was significantly more than those in non-MS group.Statistial significance were not observed in either clinic-pathological characteristics or the lesion location among two groups.2.The impact on CRC caused by components of MS:(1)In non-MS group, there existed significant difference in age of diagnosis among hypertension group and non-hypertension group(p=0.000), the age in hypertension group is generally older than non-hypertension group. Statistical significance was not observed in gender, histological grade, metastasis or the lesion location between the two groups.(2)In non-MS group, there was a significant difference in depth of infiltration among DM group and non-DM group(p=0.003),the depth of infiltration in DM group is deeper than non-DM group. There was a significant difference in age between two groups(p=0.000), the age in DM group is generally older than non-DM. Statistical significance were not observed in gender, histological grade, metastasis or the lesion location among the two groups.(3)In non-MS group, there existed significant difference in age of diagnosis among BMI?25kg/m2 group and BMI<25kg/m2group(p=0.003),the age in BMI?25kg/m2 group is generally younger. There was a significant difference in the lesion location among the two groups(p=0.001). In BMI?25kg/m2 group, tumors located more often in left colon and rectum than inBMI<25kg/m2 group. Statistical significance was not observed in gender,histological grade and metastasis between the two groups.Conclusions:1. Age of diagnosis is older in MS group, CRC with hypertension subgroup,CRC with diabetes mellitus subgroup, and CRC with BMI<25kg/m2 subgroup.2. Patients in CRC with diabetes mellitus subgroup tended to involve in deeper infiltration lesions than in all other groups.3. BMI ? 25kg/m2 and fatty liver had impact on lesion locations in synchronous CRC.Enhancing awareness in MS patients, to reduce and control the prevalence of MS and its components may benefit CRC patients in both pathological features and prognosis. Further study is necessary to investigate the correlation between MS and CRC. |
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