The Relationship Between Serum Albumin,Hemoglobin And Osteoporosis

Background: Serum albumin and hemoglobin and Studies have been shown to be associated with osteoporosis in people without diabetes, however,it is unclear whether there is a similar situation in patients with type 2 diabetes mellitus(T2DM), The purpose of this study is to investigate the relationship between serum albumin,hemoglobin and osteoporosis in diabetic patients and non-diabetic healthy human.Methods: This study is a retrospective investigation included 1654 patients with type 2diabetes(872 women and 782 men) in September 2008 to September 2015 attending the Endocrinology Department of the First Affiliated Hospital of Fujian Medical University and 1158 healthy populations of cases as a non-diabetic group(634 men and524 females) in April 2008 to September 2015 visiting Physical examination center of the First Affiliated Hospital of Fujian Medical University. The EGFR of All subjects is more than or equal to 60 ml / min. All patients underwent dual energy X-ray absorptiometry measurement, and bone mineral density of lumbar(lumbar 1-4), and femoral neck bone were recorded. According to the WHO diagnostic criteria of osteoporosis in 1994,the subjects were divided into two groups: non osteoporosis group(including normal bone mass and reduced bone mass) and osteoporosis group. We also collect information about patients gender, age, height, weight, duration of diabetes, drug use, body mass index(BMI), serum albumin, hemoglobin, serum creatinine, uric acid,blood lipid, glycosylated hemoglobin white, fasting blood glucose, serum calcium,phosphorus and other biochemical indicators. SPSS statistics software is used to carry on the sample statistic description and analysis.Results: 1. compared with the non diabetes group, diabetes group had lower ALB and HB levels, the difference was statistically significant, the differences of age and BMI between the two groups were not statistically significant.2. Non diabetes group: Compared with non osteoporosis group, male osteoporosis group had lower Hb level, the difference has statistical significance(P < 0.05), ALB level differences between the two groups did not statistically significant. With the decline of HB, the detection rate of male bone pine was increased, the difference was statistically significant(P<0.05); there was no significant difference between the level of ALB, Hb and osteoporosis in female(P>0.05). Logistic regression analysis showed that, there is a correlation between Hb level and bone osteoporosis risk ratio [OR=0.9700.951-0.990, P < 0.05]. After adjusting for age, EGFR, UA, FPG, TG, HDL-C, BMI,smoking history, history of hypertension, family history of hypertension, osteoporosis and Hb still have related [OR=0.973(0.952-0.995), P < 0.05]. However, ALB in male and ALB, Hb in female had no correlation with osteoporosis.3.The diabetic group: compared to non osteoporosis group, both male and female osteoporosis group have lower ALB level and Hb level. With the decrease of ALB and HB levels male and female osteoporosis detection rate increased,the difference has statistical significance(P < 0.05). Logistic regression analysis showed that the ALB levels and Hb level of male and female were associated with bone osteoporosis risk ratio,respectively; [male: OR=0.954(0.919-0.991), P < 0.05;O = 0.980(0.969-0.991), P< 0.001; female: OR=0.961(0.932-0.991), P < 0.05; OR=0.989(0.978-0.999), P < 0.05].After adjusting for age, SCR, Hb A1 c, TG, CA, BMI, smoking history, drinking history,medication history, history of hypertension, family history of hypertension, hemoglobin was independently related to osteoporosis in male[OR=0.984(0.972-0.996), P < 0.05].After adjusting for age, e GFR, SCr, UA, LDL-C, FPG, BMI, medication history, history of hypertension, family history of hypertension, there was no correlation between ALB,Hb and bone density in female.Conclusion: Diabetes patients have lower serum albumin and hemoglobin levels, and lower hemoglobin levels may be a marker of osteoporosis in males with or without diabetes...