Study On The Relationship Between Dinner-To-Bed Time,post Dinner Walk And Gastric Cancer

Objective:(1) To investigate the relationship among dinner-to-bed time?post-dinner walk and GC.(2) Determining the relationship between dinner-to-bed time and post-dinner walk and GC, to further analysis the effects of dinner-to-bed time and post-dinner walk on the risk for GC across different age groups.(3) According to gender and tumor location, analysis the effects of dinner-to-bed time and post-dinner walk on the risk for GC in different gender and parts.(4) According to the investigation and analysis of the results, to provide a reference for the prevention and treatment of GC.Material and method:(1) A self-questionnaire was made based on literature of risk factors for GC,consultation to clinical gastrointestinal specialists and epidemiologists. Then the questionnaire was revised, carry out the pre-investigation, reliability analysis and form the final questionnaire.(2) A case-control study was conducted in 5 hospitals, including 498 patients with GC and 498 age(within 2 years old)-, race-and gender-matched controls. A self-designed questionnaire was used to collect information on demographic characteristics, dinner-to-bed time, post-dinner walk, smoke, drink, special food habbit, fresh vegetable intake, fresh fruit intake and other behavioral factors.(3) Conditional logistic regression model was used to estimate the adjusted OR, 95%confidence interval and the possible association among dinner-to-bed time, post-dinner walk, smoke, drink and GC. The meaningful variables(OR>1, 95% CI not contain s 1) introduce nomogram model to further analyse the effects of dinner-to-bed time and post-dinner walk in the development of GC as well as their joint effects on the risk for GC across different age groups. Finally, to analyse the effects of dinner-to-bed tim e and post-dinner walk in different gender groups and different parts of GC.Results:(1) Based on the literature review and specialists inqury, a scientific and pragmatic examination questionnaire was made successfully, Which used to investigate the lifestyle of patients with GC. The two round of expert consultation response rate was100%, authority coefficient of experts was 0.872. The questionnaire reliability of each dimension was between 0.809 and 0.913, and the consistency reliability of the questionnaire was good. The correlation coefficient of Pearson was 0.76(P<0.01),which indicated that the questionnaire reliability was good. The questionnaire can be used for this research.(2) In this study, a total sample of 996 cases, the control group and the case group were 498 cases, male and female ratio is about 2:1. Individuals with dinner-to-bed time<3 h were more prone to have GC(P<0.001), and the shorter the dinner-to-bed time was, the higher was the risk for GC(t=2-2.9h: OR=2.401, t<1.9h: OR=3.977).Post-dinner non-walk was associated with a 2.2-fold increased risk for GC compared with post-dinner walk(95% CI=1.590-3.011). Participants with dinner-to-bed time<3 h who did not walk after dinner were 6.8 times likely to suffer from GC(95%CI=3.694-11.531). The multiplicative interaction between dinner-to-bed time and post-dinner walk with an adjused OR was 1.675(95% CI=1.801-3.943) and the SI was 3.037. The risk of GC due to dinner-to-bed time<3 h, post-dinner non-walk and their interaction was positively correlated with age and the most significant impact on male patients with upper GC.Conclusion:Dinner-to-bed time<3 h and post-dinner non-walk are independent risk factors for GC; the synergistic interaction between the two factros was positively related to age,which might significantly increase the risk for GC among people > 55 years old.However, this effect is most closely for male patients with upper GC.