The Relationship Between Both Metabolic Syndrome And Its Risk Factors And Human Serum Magnesium

Objective Tostudy the relationshipbetween both metabolic syndrome and its risk factors and human serum magnesium of Fujian province.Methods To collect thegeneral clinical data of 591 patients who were consecutivelyhospitalized from February 2015 to February2016,determined FPG,TG,HDL-C, serum magnesium,TC,GFR,LDL-Cof patients.(1) Allpatients were divided into metabolic syndrome group(n=284)and non metabolic syndrome group(n=307),compared the differences ofthe indexes mentioned above.(2) Patients were divided into six groupsaccording to the number of risk factors of MS(0-5),compared the differences of serum magnesium.Patients were divided into four levels according to inter-quartilerang of levels of serum magnesium, compared the differences of MS and the number of risk factors of MS.(3)Patients were respectively divided into two groups according to each component of metabolic syndrome,compared the differences of serum magnesium.(4)Analyzed the correlation between serum magnesium and both the number of risk factors of metabolic syndrome and the various cardiovascular risk factors, multiple factors regression analysis was used to analyze the independent factors associated with serum magnesium.Results(1) The levels of Serum magnesium were significantlylower in patients with MS than that without MS(0.88±0.08 VS 0.90±0.07mmol/l,P<0.05),the differences were still statistically significant(P<0.05) after adjusting for age, GFR and BMI by binary logistic regression.(2) Patients were divided into six groupsaccording to the number of risk factors of MS,compared the differences of serum magnesium by a single factor variance analysis. It was found that the levels of serum magnesium were decreased with the increasing number of risk factors,the levels of serum magnesium were significantly lower in four and five risk factors group than that in zero,one and two risk factors group;The proportion of MS was significantly higher in serum magnesium <P25(<0.84mmol/l) than that in the other groups(P<0.001),the differences of the number of risk factors of MS were statistically significant(P<0.05),it was decreased with the increasing levels of serum magnesium.(3) The levels of Serum magnesium were significantly lower in diabetic group than in non diabetic group(0.87±0.09 VS 0.91±0.07mmol/l,P<0.05), the differences were still statistically significant(P<0.05) after adjusting forage,waistcircumference,BMI,TG,HDL,GFR,medical history of hypertension by binary logistic regression.The levels of Serum magnesium were significantly lower in obesity group than in non obesity group(0.88±0.08 VS 0.90±0.08mmol/l,P<0.05), but the differences were not statistically significant(P>0.05) after adjusting for age,gender, BMI, TG,HDL,FPG,GFR and medical history of hypertension by binary logistic regression.The levels of Serum magnesium were significantly lower in high TG group than in non high TG group(0.88±0.08 VS 0.90±0.08mmol/l,P<0.05), but the differences were not statistically significant(P>0.05) after adjusting for BMI, TC,HDL-C,FPG,waist circumference and LDL-C by binary logistic regression.In hypertension group and non hypertension group, low HDL group and non low HDL group,the differences of the levels of Serum magnesium were not statistically significant(P>0.05).(4)Spearman correlation analysis showed:there was negatively correlated betweeen serum magnesium and the number of the risk factors of MS(r=-0.177, P<0.01).There was negatively correlated between FPG and serum magnesium(r=-0.186 P<0.01),multiple factors regression analysis showed:FPG was the independent factor associated with serum magnesium(P < 0.01).Conclusion(1)The levels of Serum magnesium were significantly lower in patients with MS than that without MS of Fujian province,the more risk factors of MS, the lower levels of Serum magnesium.(2) Serum magnesium and FPG was significantly negatively correlated, FPG was independently associated with serum magnesium.