Clinical Study Of Risk Factors Of Catheter-Related Blood Stream Infections In Hemodialysis Patients

ObjectiveThe purpose of this study is firstly to investigate the incidence and pathogen of catheter-related bloodstream infection who underwent hemodialysis by using Single-center retrospective analysis; and secondly to analyze risk factors that may associate with catheter-related bloodstream infection; and thirdly, to provide a reference for the preventive measures to reduce the incidence of catheter-related bloodstream infections.Methods1.Eligible patientsPatient group and the control group: Patients diagnosed with vascular access infection who were hospitalized in nephrology department of our hospital from January 2011 to January 2013 were enrolled in the patient group.Patients without vascular access infection during the same period of hospitalization were enrolled in the control group.2.Diagnostic criteriaAccording to the Ministry of Health in 2000 to develop a "hospital infection diagnostic criteria" : catheter-related bloodstream infection(catheter related blood stream infection, CRBSI) refers to bacteremia taken place in patients indwelt with intravascular devices, blood cultures drawn through a peripheral vein at least once positive, accompanied by clinical manifestations of infection, and in addition no other definite catheter bloodstream infection source. That means bloodstream infection, excluded from other part of the infection of the body, was caused only by catheter infection. Same pathogens can be found in catheter tip culture and blood culture.3.Data collectionThe relevant informations of hospitalized patients including: patient demographics, primary disease,the time of dialysis,medical history and personal medical history, laboratory results, catheterization site, catheterization time,types of bacteria,the prognosis and outcome, two groups of patients infected with the seasons.4.Prognosis and outcomeDeath, better, extubation, catheterization time, hospital stay, cost of hospitalization.5. Statistical analysis:SPSS17.0 statistical package was used. Data were analyzed by using univariate analysis combined with conditional Logistic regression. Measurement data is expressed by mean±standard deviation,comparison between groups use T test.Cout data use X2 test.P <0.05 was statistically significant.ResultsDuring the two years, among 288 cases of uremic patients in our hospital treated with deep venous catheter, 43 cases of vascular access infections were confirmed. After univariate analysis combined with conditional Logistic regression model to control confounding bias by other factors, we screened out seven risk factors that may associated with catheter-related bloodstream infection, including number of intubation, catheter indwelling time, age, primary disease leading to kidney failure, intubation position, hypoalbuminemia, infection seasons.ConclusionAnemia, hypoalbuminemia,intubation position,age,primary disease leading to kidney failure, infection season are infection risk factors of uremic patients with deep venous catheter. Early detection and intervention for these related risk factors that can prevent catheter-related infections.