Clinical Study Of Catheter-related Bloodstream Infections Of Critical Ill Patients In Intensive Care Unit

Objective: To study central venous catheter-related bloodstream infection related risk factors, etiology and it's resistance in ICU ward, thus to provide the scientific basis for diagnosis and treatment of the central venous catheter-related bloodstream infection.Materials and Methods: The clinical data, basic disease, laboratory tests, catheter circumstance and prognosis data of all patients who were preliminarily and definitely diagnosed of central venous catheter-related bloodstream infection (CRBSI) in the Ningxia Medical University General Hospital ICU ward from January 2000 to December 2008 were retrospective studied. CVC rate, incidence rate of CRBSI,fatality rate were analyzed of statistics. Basic disease, time of in ICU, time and location of CVC, potential nutrition, surgery, mechanical ventilation of patients were done Regression analysis. The etiology informations were analyzed of statistics also. P<0.05 was considered as statistically significant.Results: 40.97% severe patients in ICU ward are inserted catheter in central venous. The incidence of central venous catheter-related bloodstream infection rate is 4.32%. Injury of brain is the top of basic disease of the Infection list in patients (22 cases, 26.8%), followed by multiple injuries (18 cases, 22%), abdominal injuries (10 cases, 12.2%), etc..Basic disease ,time of in ICU, time of CVC, potential nutrition of patients are related risk factors of CRBSI. 106 pathogens and 33 species were detected from 82 cases of patients. More than half of them were Gram-positive bacteria (54 strains, 50.94%), followed by Gram-negative bacteria (39 strains, 36.80%), fungi third (13 strains, 12.26). The top three of Gram-positive bacteria are resistant to multiple antibiotics, but generally sensitive to vancomycin. The top three Gram-negative bacteria are resistant to multiple antibiotics, but generally sensitive to Imipenem.Conclusion: Central venous catheter-related bloodstream Infection rate is 4.32% in ICU wards of the Ningxia Medical University General Hospital. Basic disease ,time of in ICU, time of CVC, potential nutrition of patients are related risk factors of CRBSI. The main share of the top two pathogens were Staphylococcus and Escherichia coli, while the surface of Staphylococcus aurous and Enterococcus third. The top three of Gram-positive bacteria are generally sensitive to vancomycin. The top three Gram-negative bacteria are generally sensitive to Imipenem. Take actions to prevent CRBSI.