| Objective: To explore the relationship between atherosclerosis(AS) and C1q/TNF-related protein-3(CTRP3), C1q/TNF-related protein-9(CTRP9) in hospitalized adult patients with newly diagnosed Type 2 Diabetes Mellitus(T2DM), and analysis the correlation between CTRP3, CTRP9 and the risk factors among diabetic vascular diseases, so as to provide theoretical evidence for prevention,diagnosis and treatment of diabetes atherosclerotic lesions.Methods: Collected 196 cases of hospitalized adult patients with newly-diagnosed Type 2 Diabetes Mellitus(T2DM) who were in endocrinology department of Shanxi People's Hospital from January 2014 to June 2015 as T2 DM group randomly. According to the results of carotid artery color Doppler ultrasound examination, the patients were divided into T2 DM with atherosclerosis group(AS group, n=71 cases) and T2 DM alone group(non-AS group, n=125 cases). Randomly selected earlier age, gender, smoking status matched healthy subjects were 152 cases as control group.Analysis involved all of the patient's biochemical indexes which included glycosylated hemoglobin(Hb A1c),fasting blood glucose(FBG),2-hour postprandial blood glucose(2HPBG),triglycerides(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), total cholesterol(TC).physical examination included height, weight,body mass index(BMI), waist circumference(WC), waist HIP ratio(WHR), systolic blood pressure(SBP), diastolic blood pressure(DBP). Double antibody sandwich enzyme-linked immunosorbent assay(ELISA) serum CTRP3, CTRP9 content.All data are used SPSS17.0 software for statistical analysis, P <0.05 was considered statistically significant.Results:1. T2 DM group compared with normal control group:T2DM patients serum CTRP3, CTRP9, HDL-C were significantly lower than the control group while serum FBG, 2h PBG, HBA1 c, LDL, TC, TG, WC, WHR, BMI had the opposite result and the difference was statistically significant(P <0.01). There was no significant difference between the two groups in age, gender, smoking,BMI, HIP, SBP,DBP and LDL-C(P> 0.05).2. AS group compared with non-AS group:AS group serum CTRP3, CTRP9 were significantly lower than non-AS group patients while AS group patients' WC,HBA1 c were significantly higher than non-AS group and the difference was statistically significant(P <0.01), AS group Patients serum TC, LDL-C,FBG, BMI, SBP was significantly higher than non-AS group, the difference was statistically significant(P <0.05). Two groups of age, gender, smoking,HDL-C,2h PBG, TG, HIP, WHR, DBP was no significant difference(P> 0.05).3. Various risk factors associated with vascular lesions in patients with diabetes Logistics regression analysis :Age, smoking, BMI, WC, DBP, FBG, HBA1 c, TG, LDL-C were risk factors of diabetic atherosclerosis, CTRP3, CTRP9 were protective factor of diabetic atherosclerosis.4. The correlation of CTRP3 and CTRP9 in AS group display:CTRP3 was negatively correlated with FBG(?=-0.856,P<0.01),TG(?=-0.728,P<0.01),TC(?=-0.920,P<0.01),WC(?=-0.932,P<0.01),WHR(?=-0.354,P=0.037),DBP(?=-0.932,P=0.000).CTRP9 and age(?=-0.958,P<0.01) and BMI(?=-0.628,P<0.01)and was positively correlated with HDL-C(?=0.860,P<0.01).5. The Multiple regression analysis of CTRP3, CTRP9:WC was an independent risk factor of CTRP3's(P <0.01). Age and BMI were independent risk factors of CTRP9(P <0.01).HDL-C was CTRP9 protective factor(P<0.01).Conclusion:1. Type 2 diabetic patients CTRP3, CTRP9 compared with control group tended to decrease.2. CTRP3, CTRP9 may serve as a protective factor of diabetic vascular disease,delay the occurrence and development.3. Obese patients with dyslipidemia may cause serum CTRP3, CTRP9 reduce the secretion of vascular protective effect of weakening. |
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