Relationship Between The Change Of HBV DNA Titer And Recent Liver Function, AFP Before And After TACE Of HBV-Related Liver Cancer

Objective To explore the HBV DNA titer variation before and after TACE in patients with HBV-related liver cancer,receiving antiviral therapy,and how HBV DNA titer affect recent liver function and AFP.Methods Collect 56 Patients,for the first time accepted TACE treatment of HBV-related liver cancer,meeting the inclusion criteria and ruled out by the exclusion criteria in our hospital. Respectively, within one week before TACE, postoperatively the third day and 5-6 weeks later, each patient's HBV DNA titer, liver function,AFP are monitored once. ?According to HBV DNA titers, patients in each period are divided into high titer group, low titer group or negative group to study the variation of the frequency in the three groups. ?All liver function indicators, AFP value in the 3rd day and 5-6 weeks later after TACE are compared with preoperatives'. ?According to HBV DNA titer of the preoperative and the 3rd day postoperative,patients are divided into increased group or non-increased group to compare liver function and AFP values of the two groups. Accordi? ng to HBV DNA titer of every period,patients are divided into negative or positive group, comparing liver function and AFP values of the two groups in each period.Results ? 17 cases of preoperative HBV DNA high titer group reduce 4 cases 5-6 weeks later after TACE. ? Prothrombin time after TACE 5-6 weeks compared with the preoperative's,there is no significant difference(P = 0.381), the rest values of AFP and liver function on the 3rd day and in 5-6 weeks later after TACE compared with preoperative's,differences are significant(P <0.05). ?On the 3rd day after TACE, only the difference of ALB is significant bewteen increased group and non-increased group(P = 0.043); comparing AST, AFP and other indicators bewteen the two groups,P values are more than 0.05, and the differences are not significant. ?Comparing the indicators bewteen negative and positive group in each period:in preoperative negative group and positive group only P values of AST, ALT and ALB are less than 0.05, the differences are significant, but P values of indicators such as PT and AFP are greater than 0.05, the differences are not significant. On the 3rd day after TACE differences of ALB, PT between the two groups are significant. 5-6 weeks later after TACE,only difference of ALB is significant.Conclusions ?TACE combined antiviral treatment can effectively remove hepatitis B virus in high titer group. ?Damaged liver function by TACE restore and improve significantly 5-6weeks later after TACE. ? HBV DNA positive group have a more significantly adverse impact on Albumin synthesis than negative group. ?Damage to liver function is more serious in HBV DNA Positive group than negative group.?HBV DNA titer has no obvious effect on the AFP.