Thoracolumbar Vertebral Metastasis Involving Appendix Of Vertebra Treated By Combination Of Percutaneous Vertebroplasty And ¹²⁵I Seeds Implantation

Purpose To assess the efficacy and safety of the combination of percutaneous vertebroplasty (PVP) and 125I seed implantation for thoracolumbar vertebral metastasis involving appendix of vertebra.Methods An analysis was conducted on patients, who were treated with the combination of PVP and 125I seed implantation during the period from July 2014 to June 2015 at authors' hospital. Visual analogue scale and EORTC QLQ-C30 were determined to evaluate the therapeutic efficacy. VAS and QLQ-C30 score were calculated before the operation as well as 1 week,2,4 and 6 months after the operation. The complication also was collected.Results 29 cases were collected according to the inclusion criteria and Exclusion criteria. The mean amount of cement used for each diseased vertebral body was 3.2±1.2 mL. The mean radiation dose for each diseased appendix was 20.2±11.6 mCi. The patients were followed up for a mean of 5.4±1.2 months. After results were analyzed, we found that preoperative and postoperative VAS were 9.2±0.8,6.8±1.5,5.3±1.5,4.8±2.0,4.7±1.8(F=48.7, P<0.001); and that preoperative and postoperative EORTC QLQ-C30 were 11.3 ± 8.6,24.4±13.8,41.1 ±15.9,42.9±19.8,44.1±16.5(F= 29.8, P<0.001). The only complication was asymptomatic cement leakage.Conclusion For the treatment of thoracolumbar vertebral metastasis involving appendix of vertebra, the combination of PVP and 125I seed implantation is safe, and can relief pain and improve quality of life effectively.