| Objective: This topic system observation glycouria joint of "six fairy drinks the effectiveness of the treatment of type 2 diabetes mellitus(T2DM)and security,through the contrast before and after the treatment,observation of glycosuria joint of" six fairy drinks the clinical curative effect of treatment of T2DM,and make objective evaluation of the related indexes.Six fairy water treatment for diabetes "joint promotion of T2DM preliminary clinical research,for traditional Chinese medicine in the treatment of T2DM used to provide a safe and effective method.Methods: Extraction of henan university of Chinese medicine affiliated kaifeng hospital professor Pang Guo Ming studio and diabetes area meets the criteria for the 60 patients with type 2 diabetes,two courses of treatment(6 months).In ensuring reasonable diet and adhere to the appropriate exercise,on the basis of this topic adopts the method of self control study design,to diabetes " joint drink six fairy comparison before and after treatment,compared before treatment,treatment after 3 months,6 months after treatment,symptom integral,fasting plasma glucose(FPG),blood sugar 2 hours after meal(2 HPG),insulin resistance index(HOMA IR),insulin sensitive index(HOMA-IS),c-peptide,glycosylated hemoglobin(Hb A1C)and the change of blood lipid,curative effect evaluation at the same time.Results:(1)It will conform to the standard of 60 patients were included in the group,the male 32 cases,accounted for 53.33%,the female,28 cases(46.67%),mean age 50.25 ± 5.23 years,the two groups of gender,age and other general information,had no significant difference(P>0.05),comparable.(2)The average fasting glucose standard number of days before and after the treatment was 108.23 ± 75.97,blood sugar 2 hours after meal,the average mark was 110.33 ±76.85 days;(3)The total effective rate: the total effective rate was 83.3%,treatment of June,the total effective rate was 95%;(4)The doctor of traditional Chinese medicine symptom integral: TCM symptom score,treatment for 3 months was decreased,the difference was statistically significant(P < 0.05);June was markedly reduced the treatment,there are significant difference statistically significant(P < 0.01);Between march and June treatment group comparison,the latter down more obvious compared with the former,there are significant difference(P < 0.01).(5)The FPG:treatment in March was decreased,the difference was statistically significant(P < 0.05);June was markedly reduced the treatment,there are significant difference statistically significant(P < 0.01);Between march and June treatment group comparison,the latter down more obvious compared with the former,there are significant difference statistically significant(P < 0.01);2h PG: The march and June treatment than before treatment were significantly decreased,significant differences(P < 0.01);Between march and June treatment group comparison,the latter down more obvious compared with the former,there are significant difference(P < 0.01).(6)Hb A1C: treatment in March was decreased,the difference was statistically significant(P < 0.05);June was markedly reduced the treatment,there are significant difference statistically significant(P < 0.01);Between march and June treatment group comparison,the latter down more obvious compared with the former,there are significant difference statistically significant(P < 0.01);(7)HOMA-IR,HOMA-IS: The march than before treatment were improved,the difference was statistically significant(P < 0.05),June than before treatment were significantly improved,there are significant difference statistically significant(P < 0.01);HOMA-IR: between march and June treatment group comparison,the latter down more obvious compared with the former,there are significant difference statistically significant(P < 0.01);HOMA-IS: between march and June treatment group comparison,the latter than the former down significantly,with significant difference(P < 0.05).(8)The TC,LDL-C: in terms of regulating the TC,LDL-C,3 months after treatment the TC,LDL-C can get improved significantly,with significant difference(P < 0.01);In the aspects of adjusting TG,HDL-C: after treatment for 3 months and 6 months after treatment than before treatment were improved,including 6 months after treatment is 3 months after treatment to improve significantly,more significant difference(P < 0.01);(9)Safety analysis,the treatment group and control group in blood,urine,dung routine,liver and kidney function,electrocardiogram(ecg)index change has no statistical significance(P > 0.05),in the process of clinical no adverse reactions occurred and all patients allergic phenomenon.Conclusion: ?Effectiveness: the total effective rate was 83.3%,3 months of treatment the total effective rate was 95%,6 months of treatment confirmed glycosuria joint of "six fairy drinks in the treatment of type 2 diabetes does have certain effect;? Glycosuria tablet and six fairy drink can obviously reduce the FPG,2h PG,patients with Hb A1 c related indicators,regulating lipid metabolism disorder,and can effectively improve the clinical symptoms,initially determined its and enhance insulin sensitivity,reduce glucagon levels,improve the insulin resistance,promoting mechanism of insulin secretion and so on;?Concentration-response relationship: :in 7 or less FPG < 8 tendency for L: diabetes,5 pills,oral three times;8 FPG < or less tendency for 11 L glycosuria,8 pills three times a day orally,11 FPG 15 or less tendency for L glycosuria kang 10 pills three times a day orally can reduce fasting and postprandial 2 hours blood sugar,the preliminary determination has certain clinical concentration-response relationship;?Currency: within 6 months of treatment,along with the prolonged curative effect more exactly;?Security: in the process of treatment,did not find drug side effects obviously,value to further clinical research and the further promotion and application. |
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