Analysis Of TCM Syndrome And IL- 6、SP-D Level From Different HRCT Phentypes Of Stable COPD Patients

Objective : To explore the relationship among high-resolution CT phentype 、 TCM syndrome and the activity of systemic inflammatory reaction medium interleukin-6 and Surfactant D of stable COPD.Methods : Select patients with stable COPD in Shanxi Province people’s hospital2015.1-2015.12. All patients completed the patient’s general information and choose up150 patients according to the standard of diagnosis of COPD stabilization,completed the high resolution CT. According to the extent of emphysema and bronchial wall thickening in HRCT imaging, all patients of COPD were divided into three phenotypic.Type A:without emphysema or the existence of mild emphysema, irrespective of whether complicated with bronchial wall thickening; type E: the presence of emphysema, not associated with bronchial wall thickening; type M: both emphysema and bronchial wall thickening,According to patients’ clinical symptoms, tongue and pulse condition of traditional Chinese medicine, and divided the patients into lung qi deficiency, lung and spleen.deficiency, lung and kidney deficiency temper.Extract all of the patients peripheral blood 3 ml, using ELISA method to detect IL- 6 and SP- D concentration. Statistical analysis of collected data,.To explore the relationship among the high-resolution CT phentype、TCM syndrome type and peripheral blood of IL- 6 and SP- D.Results:(1) All patients according to the imaging manifestations of HRCT are divided into3 types, type A 45 cases, type E 52 cases, type M in 53 cases(P < 0.05).(2) HRCT phenotype with copd plateau three syndrome types by certain relevance, Lung qi deficiency type closely associated with HRCT phenotype of type A, closely associated with M type lung spleen-deficiency type, lung and kidney deficiency type and E type has relatively close relationship.(3)Among HRCT 3 kinds of phenotype, IL- 6 M type patients peripheral blood average higher than that of type A and E, P < 0.05 was statistically significant; There is no difference among the groups of patients in SP-D.Conclusion:1) HRCT as a kind of chronic obstructive pulmonary disease phenotype have certain reliability, HRCT can be quantitative analysis of emphysema and thickening of bronchial situation, can provide parting individualized treatment in patients with copd and reliable basis.2)IL- 6 is factors associated with inflammation of COPD, different radiographic phenotype of COPD patients, clinical characteristics and severity of systemic inflammation does not exactly the same. SP- D as is a kind of inflammation suppression factor has correlation with emphysema, but its significance in patients with copd stabilization.3)HRCT copd phenotype with copd stabilization has certain correlation between TCM syndrome types, lung and kidney deficiency type closely associated with emphysema; Bronchial wall thickening type have correlation with lung spleen-deficiency;Lung qi deficiency type belongs to the primary stage of copd, symptom is lighter, less acute exacerbation, patients with a better quality of life.