Hepatitis B Virus Infection In Patients With Hepatitis B And Its Clinical Significance

Incidence of hepatitis b virus infection in our country is very high and it not only damage to the liver itself and can cause organ damage outside of the liver, the kidney is one of the most common organ of the damage by the hepatitis b virus. Kidney patients with chronic hepatitis b infection status and liver tissue infection status have what relation, presence of hepatitis b virus replication in renal tissue, chronic hepatitis b virus infection in hepatorenal syndrome occurs whether combined kidney-liver transplantation are worth exploring. We collect 10 cases of hepatitis b patients with hepatorenal syndrome, autopsy take its liver and kidney tissue,using immunohistochemical staining method to detect hepatitis b virus antigen in liver, kidney, This study shows that in 10 patients with nephrotic syndrome was detected in 9 cases of HBsAg expressed, 4 cases were detected HBcAg expression; Was detected in 3 cases of renal tissue samples HBs Ag expressed, 10 cases were detected HBcAg expression. In10 patients with hepatorenal syndrome kidney tissues HBV cccDNA positive signal, not detected in the kidney tissues did not find the hepatitis b virus cccDNA copy of the original template. Results showed that the hepatitis b virus can lead to infections of the extrahepatic tissues, but not all the existence of HBV infection in patients with renal tissues can detect the virus antigen. HBV in renal local there may not be active replication, the mechanism of kidney infection is unlikely to direct...