Promoting Blood Flow And Dredging Method Treating DPN Curative Effect Observation And Research On The Correlation Of Serum NO,ET Influence

Purpose: By observing xiao ke bi tong capsule on the clinical effect of the treatment of diabetic peripheral neuropathy(DPN)(Qi deficiency and blood stasis syndrome),to explore the serum nitric oxide(NO)and endothelin(ET)role in the development process of the disease,effects of its intervention and drug treatment,and make objective evaluation on its effectiveness?Method:60 patients with DPN,randomly divided into two groups,The treatment group(n=30),give xiao ke bi tong capsule 4 grain,oral three times day;The control group(n=30),Give a piece of cobalt amine 0.5 mg,oral three times day?Two groups all take the same basic treatment,In 4 weeks for a period of treatment,application of three consecutive period of treatment?Observe two groups the change of before and after treatment of TCM syndrome integral?Bilateral and total of motor nerve conduction velocity(MCV)?Bilateral sural nerve sensory nerve conduction velocity(SCV)?blood glucose(FPG?2hPPG)?glycosylated hemoglobin(HbAlc)?NO?ET,and make a statistical analysis?Result: The treatment group is better than that in control group in improving TCM symptoms integral(P< 0.05);Treatment group for bilateral phil total MCV and the improvement of sural SCV is better than the control group(P<0.05);Lower levels of FPG?2hPPG?HbAlc is better than that of control group(P < 0.01or0.05);Elevated serum NO and reduce the level of serum ET is better than the control group(P<0.05)?Conclusion: Xiao ke bi tong capsules can make qi deficiency and blood stasis syndrome in patients with DPN of TCM symptoms improve;Can increase the serum NO,to reduce the serum levels of ET,so that the endothelial cell function improved,this may be one of diabetes,polioplus partners capsule to treat DNP mechanism,less side effects and good safety,Provide the basis for Chinese medicine treatment of DPN?...