Analysis Of Characteristic Of TCM Deficient Syndrome And Its Relationship With Laboratory Parameter In CKD4

ObjectiveThe project tries to discuss the character of TCM deficiency syndrome of CKD4 and its relative association between some laboratory parameter, in order to provide reference for the further establishment standard of TCM syndrome and clinical treatment of CKD4. And based on the above analysis,the project attempts to bring into full play the advantages of TCM on delaying progression even preventing ESRD, which benefit patients and society burden.MethodsA retrospective epidemiological investigation was conducted to analyze the character of TCM deficiency syndrome of CKD4 and its relationship between some laboratory variables including Cr, UN, UA, TG, serum total cholesterol, 24hPR0, ACR among all the 123 collected cases.ResultsIn 123 patients with CKD4, the highest rate of the patient with deficiency of Yang of the spleen and kidney was 34.38%, and the type of deficiency of Qi and Yin of the spleen and kidney was 27.64%, deficient Yang of the spleen and kidney type was 19 cases altogether, deficient Yin of the liver and kidney was 18, deficient Yin-Yang of the spleen and kidney was 7, damp-heat syndrome had only 1 case. Logistic regression analysis indicated that there were no significant differences in between deficient Qi of the spleen and kidney group and deficient Qi and Yin of the spleen and kidney group. UA was normally acknowledged between deficient Qi of the spleen and kidney+deficient Qi and Yin of the spleen and kidney group and NON-deficient Qi of the spleen and kidney+deficient Qi and Yin of the spleen and kidney group (P<0.1), and UA in the former group was higher than the latter one(P<0.05, D>0). Serum total cholesterol was significantly acknowledged between two groups of data(P<0.05), and data in the former group is usually lower than the latter one(P<0.05, D<0). ACR is also significantly acknowledged in two groups(P<0.05), and the data in former group is usually lower than the latter one(P<0.05, D<0). When using statistics to analyze data between deficient Qi of the spleen and kidney+deficient Qi and Yin of the spleen and kidney gropu and NON-deficient Qi of the spleen and kidney+deficient Qi and Yin of the spleen and kidney group, it was discovered that LDL-C, Cr, UN,TG,24hPR0 were no statistical significance.ConclusionIn 123 patients with CKD4, deficient Qi of the spleen and kidney and deficient Qi and Yin of the spleen and kidney are the main deficiency TCM syndrome, deficiency of spleen and kidney is the basic pathogenesis, but we cound not find relative association between theose two syndrome and some laboratory variables, which still needs to take a larger sample and multi-center clinical epidemiology research, and it indicated that syndrome differentiation and treatment might be more important on those two types. Furthermore, based on observation, smelling, inquiry, pulse diagnosis, high UA could be as one of the relative factors for the TCM syndrome of deficient Qi of the spleen and kidney and deficient Qi and Yin of the spleen and kidney in CKD4 patients. High ACR and total cholesterol could be the relative factors for the TCM syndrome of deficient Yang of the spleen and kidney, deficient Yin of the liver and kidney, deficient Yin-Yang of the spleen and kidney in CKD4 patients.