The Change Of Serum Tenascin-C Level And The Relationship With The Level Of Hs-CRP、cTnI In Patients With Acute Coronary Syndrome

Objective : To investigate variation trend of serum tenascin-C(TN-C)and the relationship with hs-CRP、cTnI in acute coronary syndrome(ACS)patients.Methods:This study was approved by the Medical Ethics Committee,The First Affiliated Hospital of Dalian Medical University.In this study,69 patients(46 men,23women;mean age 63.5±12.0 years)with ACS and who admitted in the First Affiliated Hospital of Dalian Medical University from June 2015 to February 2016 were enrolled.Those patients were divided into three groups.They were STEMI group who chest pain attacked within 12h(n=23),NSTEMI group(n=23)and UAP group(n=23)according to their diagnose.Normal group(NA group,n=9)were chosen in control group,who were performed angiogram and ruled out coronary artery diseases.The clinical characteristics of all patients including gender,age,history of smoking,diabetes,hypertension,family history of coronary heart disease were collected.The serum level of glycosylated haemoglobin A1c(HbA1c),fasting blood glucose(FBG),creatinine(CRE),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),high sensitivity Creactive protein(hs-CRP),and cardiac troponin I(cTnI)were recorded.The day of patients with STEMI who were performed emergency PCI was day 1.And the concentration of TN-C were also measured at day 2,3,5 and 8.All blood samples were stored at-80℃ until assayed by ELISA.All the data was analyzed by SPSS17.0 statistical software.Results: Compared with normal group,gender,age,history of smoking,diabetes,hypertension,family history of coronary heart disease,and the level of CRE,HbA1 C,TC,TG,HDL-C,LDL-C among STEMI group,NSTEMI group and UAP group had nonsignificant difference(all P>0.05).However,the serum level of FBG(STEMI group 9.30±4.20mmol/L v.s.NSTEMI group 6.31±1.34mmol/L v.s.UAP group 6.95±2.45mmol/L v.s.NA group 6.12±1.59mmol/L,P=0.002),WBC(STEMI group 9.73±2.61*10e9/L v.s.NSTEMI group 7.62±1.60*10e9/L v.s.UAP group 6.56±2.03*10e9/L v.s.NA group 7.06±1.78*10e9/L,P<0.001),hs-CRP(STEMI group 10.17±7.93mg/L v.s.NSTEMI group 3.30±2.97mg/L v.s.UAP group 1.30±1.25mg/L v.s.NA group 2.38±2.18mg/L,P<0.001)and cTnI(STEMI group 58.71±55.26ug/l v.s.NSTEMI group 4.19±3.98ug/l v.s.UAP group 0.009±0.004ug/l v.s.NA group 0.008±0.004ug/l,P<0.001)were different significantly.The serum TN-C level of STEMI patients on day 1 was(81.04±54.89ng/ml),and peaked on day 3(111.24±67.19ng/ml).Then gradually declined within eight days(TN-C level in day 8 : 89.21±53.75ng/ml).Although the serum TN-C level in NSTEMI group(84.86±51.57ng/ml)was lower than the concentration of TN-C in STEMI group,there was no significant difference between them(P=0.064).While,the TN-C level in STEMI and NSTEMI group were all higher than those of UAP Group(40.79±19.51ng/ml)and NA group(33.67±14.81ng/ml)(all P<0.05).No significant difference between UAP group and control group was found.In ACS patients,a positive correlation between the level of TN-C was found.The correlation coefficient was 0.56 and 0.392 respectively.Conclusions: The level of serum TN-C increase in patients with ACS.It was positively correlated with the level of hs-CRP and cTnI.The level of serum TN-C in patients with STEMI reached a peak at the third day after chest pain attacked.