| Objective:Aiming to observe Cystatin C (cysC) and high-sensitivity C-reactive protein(hs-CRP) levels in different types of acute coronary syndrome(ACS) and differentcoronary artery disease patients, and thus to explore its clinical significance.Methods:120subjects with chest pain, chest tightness treatment in our hospital had beenfiltered out for the study in February to July2012. The patients have been divided into4groups:66patients who were diagnosed as acute coronary syndrome (ACS) byclinical symptoms and coronary angiography (CAG),include acute myocardialinfarction(AMI) group(n=36),and unstable angina pectoris(UAP) group(n=30), stableangina (SAP) group(n=28),normal control group (n=26). According to the Syntaxscoring system,94patients with coronary artery disease can be classified into threegroups: mild group(0-22points), moderate group(23-32points), severe group(morethan33points). Serums of all subjects were timely collected, and quantitativedetection of serum CysC hs-CRP, Cr, and cTnI, the levels of detected indexes betweenthe groups have been compared and analyze the relation among CysC、hs-CRP andthe degree of coronary artery lesions.Results:1. The CysC, hs-CRP, cTnI levels in ACS group (AMI and UAP groups) weresignificantly higher than SAP and control group, and AMI group were significantlyhigher than control group; Cr levels in the four groups have no significant difference.2. In different coronary artery lesions groups, the gradual increased CysC andhs-CRP levels in the mild group, moderate group and the severe group have statistical significance（p<0.05）; the levels of cTnI mild, moderate group of the severe grouphave statistical significance（p <0.05）; but the levels of Cr in the each group have nostatistically significance（p>0.05）.3. CysC was in positive proportion to hs-CRP（p <0.05）.Conclusion:1. CysC and hs-CRP could be valuable predictor of ACS.2. The level of serum cystatin and hs-CRP could indirectly reflect the severity ofcoronary artery disease. |
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