| Objective: This experiment through the observation of Qinghao Biejia Decoction Decoction in the treatment of lupus nephritis patients with the clinical efficacy and to provide clinical evidences for the treatment of lupus nephritis.Method: This experiment using randomized controlled methods,selected patients with lupus nephritis who accept treatment during June 2014 to December 2015 in Hubei Province Chinese medicine hospital.divided into trial group and control group,20 cases in each group,two groups of patients were given conventional treatment.The experimental group based on the use of Chinese medicine Jiawei Qinghao Biejia Decoction(artemisia annua,turtle shell,rehmanniae,rhizoma anemarrhenae,paeonol,red peony root)and clinical observation was performed for 3 months,were recorded before and after treatment for 1 months,2 months,3 months in the laboratory indicators;indicators including urine red blood cell count,24 hour urinary protein,serum albumin,blood urea nitrogen,serum creatinine,ESR,C3,HGB,the stool routine,electrocardiogram,liver function as safety index,the data were used SPSS17.0 statistical software for medical statistics analysis of experimental data,use the mean and standard deviation in the form of data was compared between the two groups and within group comparison data using t test,count data using X2 Test;when the calculated P<0.05 statistics Learn the difference;P<0.01 said there was a significant difference;P>0.05 was not statistically significant.Result: 1 Disease curative effect comparison of two groups: Five cases of experimental group,complete remission,basic mitigation of eight,improved five,invalid two,statistics of the total efficiency is 90%;Three cases in the control group,the complete remission,basic relief in eight,improved in five,invalid four,statistics of the total efficiency was 80%.The conclusion is that in the experimental group was better than the control group(P < 0.05).2 Traditional Chinese medicine syndrome curative effect comparison of two groups: There are six cases of test group in clinical cure,eight markedly,effective four,invalid two,statistics of the total effective rate was 90%;control group,clinical cure case three,the effective eight,effective six,invalid three,statistics the total effective rate was 85%;in the experimental group was better than the control group(P < 0.05).3 Comparison of the total score of TCM symptoms between the two groups: There was no significant difference between the two groupsbefore treatment(P>0.05);After treatment,there were significant differences between the data before treatment and after treatment(P<0.05).After treatment,compared with the control group,there were significant differences(P<0.05),the experimental group was better than the control group.4 Comparison of TCM symptom scores before and after treatment in two groups: There was no significant difference between the two groups before treatment(P>0.05);In the two groups after treatment and before treatment have significant difference in comparison(P < 0.05);two groups between individual symptoms after comparison,facial redness,fever,hair loss,joint pain,edema,irritability and other symptoms were significant difference(P < 0.05).In the experimental group was better than the control group.5 Comparison of lupus activity index scores in two groups before and after treatment: There was no significant difference between the two groups before treatment(P>0.05);In the two groups after treatment,1 month,2 month,before and after three months compared with significant difference(P < 0.05);between the two groups after treatment 1 month,2 months,P value was less than 0.01,treatment after 3 month p value of 0.04 and had significant difference(P < 0.05),the experimental group was better than control group.6 Comparison of ESR,C3,HGB between two groups before and after treatment: There was no significant difference between the two groupsbefore treatment(P>0.05);After treatment in two groups in 1 month,2 month,3 month and before treatment were significantly different(P<0.05);treatment in 1 month,2 month,3 month,the two groups were significantly different(P<0.05),the test group was better than the control group.7 Comparison of urinary red blood cell count and 24 h urinary protein in two groups: There was no significant difference between the two groups before treatment(P>0.05);After treatment in two groups in 1 month,2 month,3 month and before treatment were significantly different(P<0.05);after 1 month,2 month,3 month,there were significant differences between the two groups(P<0.05),the experimental group was better than the control group.8 Comparison of serum creatinine?blood urea nitrogen?HGB in two groups: There was no significant difference between the two groups before treatment(P>0.05);After treatment in the two groups before treatment and compared the differences were statistically significant(P < 0.05).Between the two groups after treatment,serum creatinine,blood urea nitrogen,HGB P value is 0.02,<0.01 and 0.02,a statistically significant difference(P < 0.05).In the experimental group was better than the control group.9 security comparison: The two groups before and after treatment of liver function,blood routine,stool routine,electrocardiogram showed nosignificant difference(P>0.05).Conclusion: This study indicates that the Qinghao Biejia Decoction on the treatment of active lupus nephritis patients have significant clinical efficacy in improving laboratory,reduce the clinical symptom score especially reduce the skin disease and fever symptoms were better than only routine treatment control group,it is worth utilizing wideiy in the clinic. |
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