Reseach Of Oxidative Stress And Cognitive Function In Schizophrenia Ultra High-risk Groups

Objective: To compare the differences of blood oxidative stress and cognitive functions between ultra-high-risk populations of schizophrenia and healthy population; in addition, to find the relationship between oxidative stress and cognitive function; what's more, to explore whether the detection of oxidative stress and cognitive function offer some possibilities for the early identification and treatment of schizophrenia.Methods: 30 groups of ultra-high-risk populations of schizophrenia and 30 groups of healthy subjects were enrolled respectively, and then two of each blood samples were taken to measure the superoxide dismutase(SOD), glutathione peroxidase(GSH-PX), peroxide catalase(CAT), malondialdehyde. At the same time checking the neurocognitive function, and Using complete cognitive tests- consensus version of schizophrenia(MCCB) continuous reaction test(CPT), Hopkins vocabulary learning test- revision(HVLT- R),the verbal fluency test(VFT), and the stroop colour word test. Comparing two groups' differences between oxidative stress and cognitive function by using statistical SPSS17.0,as a result,to find the relation between oxidative stress and cognitive function in ultra-high-risk populations of schizophrenia.Results: 1, the general situation between the two groups: it shows thata schizophrenia ultra-high-risk group and the healthy group have no significant differences in gender, age, smoking, level of education. By chi-square test, P > 0.05,suggesting that biological characteristics of the two groups comparability.2, Cognitive function between the two groups: According to the scores in Continuous Performance Test(CPT), the words in the verbal fluency test(VFT), Hopkins vocabulary learning test- revision(HVLT- R)), stroop color word test, ultra-high-risk group scored significantly lower than the healthy group(p <0.01).3. Comparing the oxidative stress:ultra-high-risk group is higher than the healthy group(P <0.01) in the level of the superoxide dismutase(SOD), malondialdehyde(MDA), while ultra-high-risk group is lower than healthy group(P <0.01) in glutathione peroxidase enzyme(GSH-PX)levels, There is no significant differences in catalase(CAT) between the two groups.4, Ultra-high-risk group of schizophrenic's relationship between oxidative stress and cognitive function: Using the multiple-unit correlation analysis: it shows that superoxide dismutase(SOD), malondialdehyde(MDA) and glutathione peroxidase(gsh-px) and catalase(CAT) has nothing to do with the CPT, VFT, HVLT- R, stroop words, color, color word test(P > 0.05).Conclusion: 1, ultra-high risk of schizophrenia has some damages in attention,vigilance, information processing speed, working memory, verbal learning. 2,in the period of ultra-high risk of schizophrenia, it is different from normal in SOD, MDA,CAT, GSH-PX,and it shows that oxidative stress of schizophrenia had existed abnomally in the early phase.3,There is no significant correlation between oxidative stress of ultra-high risk of schizophrenia and cognitive function.4, Oxidative stress related indicators and cognitive function, these both can use for early diagnosis and early intervention in schizophrenia as phenotype.